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Iodonium Analogs as Inhibitors of NADPH Oxidases and other Flavin Dehydrogenases and their Use for Treating Cancer

Abstract: Diverse human cancers like colorectal, pancreatic, ovarian, melanoma, and pre-cancers express NADPH oxidases (NOX) at high levels. Reactive oxygen species (ROS) produced from metabolic reactions catalyzed by NOX in tumors are essential to the tumor’s growth. Though drugs that inhibit ROS production by NOX could be effective against a variety...

Published: 4/8/2024 | Inventor(s): James Doroshow, Prabhakar Risbood, Jaimo Lu, Krishnendu Roy, Md Tafazzai Hossian

Keywords(s): Diphenylene Iodonium, Di-thienyl-iodonium, Doroshow, DPI, DTI, Flavin Dehydrogenases, NADPH oxidases, NOX, Pre-cancerous Lesions, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer

Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer

Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics