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Iodonium Analogs as Inhibitors of NADPH Oxidases and Other Flavin Dehydrogenases for the Treatment of Cancer and Inflammatory Conditions

Summary: The National Cancer Institute (NCI) seeks licensees for the further development of a family of novel iodonium analogs as therapeutics for cancer and/or chronic inflammatory conditions. Description of Technology: Diverse human cancers like colorectal, pancreatic, ovarian, melanoma, and pre-cancers express NADPH oxidases (NOX) at high levels....

Published: 2/23/2026 | Inventor(s): James Doroshow, Prabhakar Risbood, Jaimo Lu, Krishnendu Roy, Md Tafazzai Hossian

Keywords(s): Diphenylene Iodonium, Di-thienyl-iodonium, Doroshow, DPI, DTI, Flavin Dehydrogenases, NADPH oxidases, NOX, Pre-cancerous Lesions, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer

Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...

Published: 4/22/2025 | Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer

Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics