Search Results - james+mitchell

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Nitroxide Radical as a Treatment for Neurodegeneration

Abstract: The Human Iron Metabolism Section of the National Institute of Child Health and Human Development (NICHD) is seeking statements of capability or interest from parties interested in collaborative research to obtain pre-clinical data to be used to further develop, evaluate, or commercialize nitroxide radicals as a treatment for neurodegeneration...

Published: 4/8/2024 | Inventor(s): Tracey Rouault, James Mitchell, Murali Cherukuri, Manik Ghosh, Wing-Hang Tong

Keywords(s): iron deficiency, NITROXIDE

Category(s): Collaboration Sought > Licensing, Application > Therapeutics

Denoising of Dynamic Magnetic Resonance Spectroscopic Imaging Using Low Rank Approximations in the Kinetic Domain

Abstract: Accurate measurement of low metabolite concentrations produced by medically important enzymes is commonly obscured by noise during magnetic resonance imaging (MRI). Measuring the turnover rate of low-level metabolites can directly quantify the activity of enzymes of interest, including possible drug targets in cancer and other diseases. Noise...

Published: 4/8/2024 | Inventor(s): Jeffery Brender, Kazutoshi Yamamoto, Jeeva Munasinghe, Shun Kishimoto, Hellmut Merkle, Murali Cherukuri, James Mitchell

Keywords(s): 13C imaging, Brender, Denoising, DNP, Dynamic Nuclear Polarization, Glucose Metabolism, Low Metabolite Concentration, Magnetic Resonance Imaging, Metabolic Enzymes, MRI, Software Plugin, SPECTROSCOPIC

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

Tempol: A Commercially-Available Nitroxide as a Cancer Therapeutic

Abstract: The National Cancer Institute's Urologic Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of Tempol to target HIF-2a in cancer. Elevated HIF-2a is associated with clear cell kidney cancer characterized by mutation of the...

Published: 4/8/2024 | Inventor(s): William Linehan, Tracey Rouault, James Mitchell, Murali Cherukuri

Keywords(s): clear cell, HIF-2, kidney cancer, NITROXIDE, Tempol

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

NSAIDs that Assist the Treatment of Human Diseases

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to treat a variety of inflammatory conditions. Many of these conditions, such as cancer or arthritis, require long term use of the NSAIDs due to the chronic nature of the disease. However, the NSAIDs in current use have toxicities associated with their long-term use that...

Published: 4/8/2024 | Inventor(s): David Wink, Wilmarie Flores-Santana, S. Bruce King, Murali Cherukuri, James Mitchell

Keywords(s): David Wink, HNO, Inflammation, nitric oxide, NITROXYL, non-steroidal anti-inflammatory drugs, NSAID

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Immunology

Video Monitoring and Analysis System for Vivarium Cage Racks

Abstract: This invention pertains to a system for continuous observation of rodents in home-cage environments with the specific aim to facilitate the quantification of activity levels and behavioral patterns for mice housed in a commercial ventilated cage rack. The home-cage in-rack provides daytime and nighttime monitoring with the stability and consistency...

Published: 4/8/2024 | Inventor(s): James Mitchell, Ghadi Salem, Thomas Pohida

Keywords(s): behavior analysis, home-cage, VIDEO, vivarium monitoring

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

mTOR Inhibition for the Prevention of Epithelial Stem Cell Loss and Mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on self-renewing stem cells and, therefore, is vulnerable to physical and chemical damage from common cancer treatments, such as radiation or chemotherapy. Consequently, many cancer patients undergoing these treatments develop mucositis, a debilitating condition involving painful...

Published: 7/25/2024 | Inventor(s): Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana Cotrim, Alfredo Molinolo, James Mitchell, J Silvio Gutkind

Keywords(s): CBXXXX, Cell, CXXXXX, Epithelial, inhibition, mTOR, Mucositis, PREVENTS, PROTECTS, Radiation-induced, Senescence, Stem

Category(s): Application > Therapeutics, TherapeuticArea > Oncology