Search Results - inhibition

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Discovery of Proteasome Inhibitors to Target PMP22 Gene Expression for the Treatment of Charcot-Marie-Tooth Disease Type 1A

This technology includes the use of proteasome inhibitors, such as Bortezomib, for the treatment of the most prevalent form of Charcot-Marie-Tooth disease type 1A (CMT1A). Duplication of the peripheral myelin protein 22 (PMP22) gene, normally involved in myelination of the peripheral nervous system, is the causative agent in most forms of CMT1A. A drug...

Published: 7/25/2024 | Inventor(s): Sung-Wook Jang, John Svaren, James Inglese

Keywords(s): Discovery, DOWN, Expression, Gene, inhibition, Listed LPM Tong as of 4/15/2015, MEANS, Pmp22, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Proteasome, REGULATE, VEXXXX, WKXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology

Inhibition of HIV Infection through Chemoprophylaxis Using Emtricitabine and Tenofovir

The invention is directed to prophylactic administration of emtricitabine (FTC) in combination with tenofovir or its prodrug, tenofovir disoproxil fumarate (TDF), to protect against transmission of human immunodeficiency virus (HIV) infection. Also disclosed are other nucleoside reverse transcriptase inhibitors (NRTIs) and nucleotide reverse transcriptase...

Published: 7/25/2024 | Inventor(s): Thomas Folks, Robert Janssen, Ronald Otten, Jose Garcia Lerma, Walid Heneine

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Chemoprophylaxis, HIV, Infection, inhibition, OID-NCHHSTP-DHPSE, VLXXXX, WMXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products

mTOR Inhibition for the Prevention of Epithelial Stem Cell Loss and Mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on self-renewing stem cells and, therefore, is vulnerable to physical and chemical damage from common cancer treatments, such as radiation or chemotherapy. Consequently, many cancer patients undergoing these treatments develop mucositis, a debilitating condition involving painful...

Published: 7/25/2024 | Inventor(s): Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana Cotrim, Alfredo Molinolo, James Mitchell, J Silvio Gutkind

Keywords(s): CBXXXX, Cell, CXXXXX, Epithelial, inhibition, mTOR, Mucositis, PREVENTS, PROTECTS, Radiation-induced, Senescence, Stem

Category(s): Application > Therapeutics, TherapeuticArea > Oncology

Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine

NIH inventors at the Vaccine Research Center have developed a novel influenza virus hemagglutinin (HA)-ferritin nanoparticle influenza vaccine that is easily manufactured, potent, and elicits broadly neutralizing influenza antibodies against multiple strains of influenza. This novel influenza nanoparticle vaccine elicited two types of broadly neutralizing,...

Published: 7/25/2024 | Inventor(s): Masaru Kanekiyo, Jeffrey Boyington, Gary Nabel

Keywords(s): assay, DC5BXX, DC5XXX, DCXXXX, Development, DXXXXX, Ferritin, HA-Ferritin, HEMAGGLUTINATION, HEMAGGLUTININ, INFLUENZA, inhibition, Nanoparticles, SELF-ASSEMBLING, Vaccine

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines