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Discovery of Proteasome Inhibitors to Target PMP22 Gene Expression for the Treatment of Charcot-Marie-Tooth Disease Type 1A
Case ID:
TAB-3605
Web Published:
12/6/2022
Description:
This technology includes the use of proteasome inhibitors, such as Bortezomib, for the treatment of the most prevalent form of Charcot-Marie-Tooth disease type 1A (CMT1A). Duplication of the peripheral myelin protein 22 (PMP22) gene, normally involved in myelination of the peripheral nervous system, is the causative agent in most forms of CMT1A. A drug discovery program was initiated and found that proteasome inhibitors can be used to target PMP22.
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Direct Link:
https://nih.technologypublisher.com/tech/Discovery_of_Proteasome_Inhibitors_t o_Target_PMP22_Gene_Expression_for_the_Treatment_of_Charcot-Marie-Tooth_Dise ase_Type_1A
Category(s):
Therapeutics
Neurology
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For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Sung-Wook Jang
John Svaren
James Inglese
Keywords:
Discovery
DOWN
Expression
Gene
inhibition
Listed LPM Tong as of 4/15/2015
MEANS
Pmp22
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Proteasome
REGULATE
VEXXXX
WKXXXX
XEXXXX
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