Search Results - walid+heneine

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Improved simian HIV (SHIV) prevention in non-human primate models with chemoprophylaxis combination that can be taken in one or two oral doses before or after exposure

HIV and AIDS remain persistent problems for the United States and countries around the world. In 2015, nearly 40,000 people were diagnosed with HIV in the US alone. Pre-exposure prophylaxis (PrEP) can help prevent HIV infections in people who are not infected with HIV but are at high risk of becoming infected with HIV. PrEP involves taking daily medications...

Published: 7/25/2024 | Inventor(s): Ivana Massud, Walid Heneine, Jose Garcia Lerma

Keywords(s): Chemoprophylaxis, Combinations, Containing, HIV, Improved, Inhibitors, Integrase, NCHHSTP, NCHHSTP-DHAP, Reverse, TRANSCRIPTASE

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Inhibition of HIV Infection through Chemoprophylaxis Using Emtricitabine and Tenofovir

The invention is directed to prophylactic administration of emtricitabine (FTC) in combination with tenofovir or its prodrug, tenofovir disoproxil fumarate (TDF), to protect against transmission of human immunodeficiency virus (HIV) infection. Also disclosed are other nucleoside reverse transcriptase inhibitors (NRTIs) and nucleotide reverse transcriptase...

Published: 7/25/2024 | Inventor(s): Thomas Folks, Robert Janssen, Ronald Otten, Jose Garcia Lerma, Walid Heneine

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Chemoprophylaxis, HIV, Infection, inhibition, OID-NCHHSTP-DHPSE, VLXXXX, WMXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products

Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance of HIV

This novel assay features real-time PCR reagents and methods for detecting drug-resistance related mutations in HIV, for newly diagnosed patients and those individuals currently receiving antiretroviral therapies. As the use of antiretroviral compounds to treat HIV infection proliferates, viruses adapt and evolve mutations limiting the efficacy of...

Published: 7/25/2024 | Inventor(s): Jonathan Lipscomb, Walid Heneine, Jeffrey Johnson

Keywords(s): 1, ANTIVIRAL, Anti-Viral, ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4XXX, DAXXXX, DETECTING, DRUGS, DXXXXX, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, MUTATION, NCHHSTP-DHPSE, OID-NCHHSTP-DHPSE, PCR, POINT, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REAL-TIME, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, XBXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology, Application > Research Materials, ResearchProducts > Computational models/software, Application > Consumer Products, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samples

CDC researchers have developed methods for detecting retroviruses within a patient blood sample and discriminating HIV-1 samples within serum specimens. HIV-1 can be genetically classified into two major groups, group M (major) and Group O (outlier) with group O comprising all divergent viruses that do not cluster with group M. The identification of...

Published: 4/8/2024 | Inventor(s): Thomas Folks, Shinji Yamamoto, William Switzer, Walid Heneine

Keywords(s): Activity, assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DXXXXX, Methods, OID-NCHHSTP-DHPSE, Reverse, RT, SENSITIVE, TRANSCRIPTASE, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products

Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples

One of the problems with the development of current therapies for HIV infection is that the virus rapidly develops resistance to drugs such as reverse transcriptase (RT) inhibitors. CDC researchers have developed an enzyme-based methodology for detecting phenotypic resistance to antiretroviral drugs whose mode of action decreases the efficiency of...

Published: 7/25/2024 | Inventor(s): Gerardo Lerma, Shinji Yamamoto, William Switzer, Thomas Folks, Walid Heneine

Keywords(s): ANTIVIRAL, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, DB4AXX, DETECTING, DRUGS, DXXXXX, KIT, Method, OID-NCHHSTP-DHPSE, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics

Novel Primate T-cell Lymphotropic Viruses (HTLV, STLV) for Development of Diagnostics, Therapeutics, Research Tools, and Vaccines

CDC researchers have isolated and characterized the novel primate T-lymphotropic viruses denoted human T-lymphotropic viruses 3 and 4 (HTLV-3 and HTLV4), that are believed to have resulted from cross-species transmission at some point in the past. It has been previously established that HTLV-1 causes adult T cell leukemia and other inflammatory diseases;...

Published: 7/25/2024 | Inventor(s): William Switzer, Walid Heneine, Thomas Folks

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, OID-NCHHSTP-DHPSE, OID-NCHHSTP-DSTDP, primate, T-LYMPHOTROPIC, Viruses, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Diagnostics, Application > Occupational Safety and Health