HOME
SEARCH
RSS FEED
SUBSCRIBE
Improved simian HIV (SHIV) prevention in non-human primate models with chemoprophylaxis combination that can be taken in one or two oral doses before or after exposure
Case ID:
TAB-3162
Web Published:
12/6/2022
Description:
HIV and AIDS remain persistent problems for the United States and countries around the world. In 2015, nearly 40,000 people were diagnosed with HIV in the US alone. Pre-exposure prophylaxis (PrEP) can help prevent HIV infections in people who are not infected with HIV but are at high risk of becoming infected with HIV. PrEP involves taking daily medications and is the most effective when medications are taken consistently. However, many people find it challenging to adhere to a daily pill schedule and cannot fully benefit from PrEP. CDC researchers have developed a medication dosing regimen with a combination consisting of a pharmacokinetic enhancer, integrase inhibitor, and nucleoside reverse transcriptase inhibitors that can be effective in primates against simian HIV if taken in one or two pill doses either immediately before or after SHIV exposure to prevent infection. Initial research has likely shown success in protecting against simian HIV infection in primates who received a combination of emtricitabine, tenofovir alafenamide, elvitegravir, and cobicistat (referred to as FTC/TAF/EVG/COBI). Further research would be needed to determine if this limited dosing regimen could prevent HIV (for humans), increase medication adherence, lower costs, and reduce potentially harmful side effects of daily chemoprophylaxis.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech/Improved_simian_HIV_(SHIV)_preventio n_in_non-human_primate_models_with_chemoprophylaxis_combination_that_can_be_ taken_in_one_or_two_oral_doses_before_or_after_exposure
Category(s):
Collaboration
Licensing
Bookmark this page
Download as PDF
For Information, Contact:
Jeremiah Mitzelfelt
NIH Technology Transfer
301-443-8518
jeremiah.mitzelfelt@nih.gov
Inventors:
Ivana Massud
Walid Heneine
Jose Garcia Lerma
Keywords:
Chemoprophylaxis
Combinations
Containing
HIV
Improved
Inhibitors
Integrase
NCHHSTP
NCHHSTP-DHAP
Reverse
TRANSCRIPTASE
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum