Search Results - thomas+folks

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Inhibition of HIV Infection through Chemoprophylaxis Using Emtricitabine and Tenofovir

The invention is directed to prophylactic administration of emtricitabine (FTC) in combination with tenofovir or its prodrug, tenofovir disoproxil fumarate (TDF), to protect against transmission of human immunodeficiency virus (HIV) infection. Also disclosed are other nucleoside reverse transcriptase inhibitors (NRTIs) and nucleotide reverse transcriptase...

Published: 7/25/2024 | Inventor(s): Thomas Folks, Robert Janssen, Ronald Otten, Jose Garcia Lerma, Walid Heneine

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Chemoprophylaxis, HIV, Infection, inhibition, OID-NCHHSTP-DHPSE, VLXXXX, WMXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products

Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retroviruses

CDC scientists have developed multiple antigenic peptide immunoassays for the detection of human immunodeficiency virus (HIV) and/or simian immunodeficiency virus (SIV). HIV can be subdivided into two major types, HIV-1 and HIV-2, both of which are believed to have originated as result of zoonotic transmission. Humans are increasingly exposed to...

Published: 7/25/2024 | Inventor(s): Clement Ndongmo, Chou-Pong Pau, William Switzer, Thomas Folks, Marcia Kalish

Keywords(s): ANTIGENIC, assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DXXXXX, HIV, MULTIPLE, OID-NCHHSTP-DHPSE, Peptide, Retroviruses, Serologic, SEROLOGICAL, SIV, TYPE, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, ResearchProducts > Antibodies, Application > Therapeutics

Detection of Retroviruses and HIV-1 Groups -M and -O Discrimination within Clinical Serum Samples

CDC researchers have developed methods for detecting retroviruses within a patient blood sample and discriminating HIV-1 samples within serum specimens. HIV-1 can be genetically classified into two major groups, group M (major) and Group O (outlier) with group O comprising all divergent viruses that do not cluster with group M. The identification of...

Published: 4/8/2024 | Inventor(s): Thomas Folks, Shinji Yamamoto, William Switzer, Walid Heneine

Keywords(s): Activity, assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DXXXXX, Methods, OID-NCHHSTP-DHPSE, Reverse, RT, SENSITIVE, TRANSCRIPTASE, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products

Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples

One of the problems with the development of current therapies for HIV infection is that the virus rapidly develops resistance to drugs such as reverse transcriptase (RT) inhibitors. CDC researchers have developed an enzyme-based methodology for detecting phenotypic resistance to antiretroviral drugs whose mode of action decreases the efficiency of...

Published: 7/25/2024 | Inventor(s): Gerardo Lerma, Shinji Yamamoto, William Switzer, Thomas Folks, Walid Heneine

Keywords(s): ANTIVIRAL, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, DB4AXX, DETECTING, DRUGS, DXXXXX, KIT, Method, OID-NCHHSTP-DHPSE, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics

Novel Primate T-cell Lymphotropic Viruses (HTLV, STLV) for Development of Diagnostics, Therapeutics, Research Tools, and Vaccines

CDC researchers have isolated and characterized the novel primate T-lymphotropic viruses denoted human T-lymphotropic viruses 3 and 4 (HTLV-3 and HTLV4), that are believed to have resulted from cross-species transmission at some point in the past. It has been previously established that HTLV-1 causes adult T cell leukemia and other inflammatory diseases;...

Published: 7/25/2024 | Inventor(s): William Switzer, Walid Heneine, Thomas Folks

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, OID-NCHHSTP-DHPSE, OID-NCHHSTP-DSTDP, primate, T-LYMPHOTROPIC, Viruses, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Diagnostics, Application > Occupational Safety and Health

Plasmid pNL4-3, HIV Clone For Easy Mutational Changes

Plasmid DNA (clone pNL4-3) that produces infectious HIV-1 virus particles in a wide variety of cells as described in the J Virol. 1986 Aug;59(2):284-91 and developed in the laboratory of Dr. Malcolm Martin at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): John Leonard, Malcolm Martin, Rosamond Rutledge-Burns, Theodore Theodore, Ronald Willey, Thomas Folks, Akio Adachi, Arnold Rabson

Keywords(s): 114, AIDS Research & Reference Reagent Program, CHANGES, CLONES, DDXXXX, DNA, EASY, HIV, INFECTIOUS, Listed LPM Ano as of 4/15/2015, MUTATIONAL, Novel, PLASMID, pNL4-3, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease