Search Results - mtor

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Methods for Selection of Cancer Patients and Predicting Efficacy of Combination Therapy

Abstract: Available for licensing from the Laboratory of Cancer Biology and Genetics of the National Cancer Institute (NCI) is a novel gene signature of thirty-seven drug-responsive genes that links changes in gene expression to the clinically desirable outcome of improved overall survival. Expression of these genes has been linked to prognosis in several...

Published: 4/8/2024 | Inventor(s): Beverly Mock, John Simmons, Aleksandra Michalowski, Jyoti Patel

Keywords(s): Histone Deacetylase (HDAC), MELANOMA, mTOR, Myeloma, Rapamycin

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

mTOR Inhibition for the Prevention of Epithelial Stem Cell Loss and Mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on self-renewing stem cells and, therefore, is vulnerable to physical and chemical damage from common cancer treatments, such as radiation or chemotherapy. Consequently, many cancer patients undergoing these treatments develop mucositis, a debilitating condition involving painful...

Published: 7/25/2024 | Inventor(s): Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana Cotrim, Alfredo Molinolo, James Mitchell, J Silvio Gutkind

Keywords(s): CBXXXX, Cell, CXXXXX, Epithelial, inhibition, mTOR, Mucositis, PREVENTS, PROTECTS, Radiation-induced, Senescence, Stem

Category(s): Application > Therapeutics, TherapeuticArea > Oncology