Search Results - rapamycin

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Methods for Selection of Cancer Patients and Predicting Efficacy of Combination Therapy

Abstract: Available for licensing from the Laboratory of Cancer Biology and Genetics of the National Cancer Institute (NCI) is a novel gene signature of thirty-seven drug-responsive genes that links changes in gene expression to the clinically desirable outcome of improved overall survival. Expression of these genes has been linked to prognosis in several...

Published: 4/8/2024 | Inventor(s): Beverly Mock, John Simmons, Aleksandra Michalowski, Jyoti Patel

Keywords(s): Histone Deacetylase (HDAC), MELANOMA, mTOR, Myeloma, Rapamycin

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Prevention of Head and Neck Cancer Using Rapamycin and Its Analogs

It is frequently observed in head and neck squamous cell carcinoma (HNSCC), a cancer occurring mostly in the mouth, that the Akt/mTOR pathway is abnormally activated. Therefore, inhibiting this signaling pathway may help in treating this disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they could serve as...

Published: 10/28/2024 | Inventor(s): Panomwat Amornphimoltham, Rakefet Czerninski, Vyomesh Patel, Alfredo Molinolo, J Silvio Gutkind

Keywords(s): (4)r syndrome, C syndrome, Carcinoma, CBXXXX, CHEMOPREVENTIVE, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Cowden's disease, Cowden's syndrome, CXXXXX, G syndrome, HEAD, Hypertelorism with esophageal abnormality and hypospadias, Listed LPM Campbell as of 4/15/2015, MTOR-inhibitors, N syndrome, NECK, Patent Category - Biotechnology, Patent Category - Chemistry, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Rapamycin, SQUAMOUS, Squamous cell carcinoma, Syndrome X, W syndrome, W syndrome; Syndrome W

Category(s): Application > Therapeutics, TherapeuticArea > Oncology