Search Results - nanoparticles

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Stabilized Influenza Hemagglutinin Stem Region Trimers and Uses Thereof

An effective universal influenza vaccine would eliminate the uncertain and costly process of seasonal influenza vaccine development each year. Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) are developing immunogens which elicit neutralizing antibodies to the highly conserved stem region of the influenza viral protein...

Published: 7/25/2024 | Inventor(s): Jeffrey Boyington, Hadi Yassine, Peter Kwong, Masaru Kanekiyo, Barney Graham, John Mascola

Keywords(s): Broad, Development, ELICIT, HEMAGGLUTININ, IMMUNE, INFLUENZA, Listed LPM Thalhammer-Reyero as of 4/15/2015, Modified, Nanoparticles, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RESPONSE, Stem

Category(s): Collaboration Sought > Licensing

Protein Nanoparticles for Antigen Display in Vaccines

The technology relates to a protein-based nanoparticle platform that allows presentation of immunogenic molecules such as influenza virus antigens. This protein platform is made up of hepatitis B capsid/core proteins. The core proteins contain immunogenic loop c/e1, where other antigens can be inserted and the chimeric protein retains the ability to...

Published: 7/25/2024 | Inventor(s): Dustin McCraw, Audray Harris

Keywords(s): ANTIGEN, DC5BXX, DISPLAY, INFLUENZA, Nanoparticles, Protein, Vaccine, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease

Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast

The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod...

Published: 7/25/2024 | Inventor(s): Jinhao Gao, Zhenghuan Zhao, Xiaoyuan (Shawn) Chen

Keywords(s): Agents, CA2CXX, Contrast, High-Performance, IMAGING, IRON, Magnetic, Nanoparticles, Non-spherical, OXIDE, PXXXXX, Resonance, T2, VCXXXX, VDXXXX, WBXXXX, XFXXXX, XGXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine

NIH inventors at the Vaccine Research Center have developed a novel influenza virus hemagglutinin (HA)-ferritin nanoparticle influenza vaccine that is easily manufactured, potent, and elicits broadly neutralizing influenza antibodies against multiple strains of influenza. This novel influenza nanoparticle vaccine elicited two types of broadly neutralizing,...

Published: 7/25/2024 | Inventor(s): Masaru Kanekiyo, Jeffrey Boyington, Gary Nabel

Keywords(s): assay, DC5BXX, DC5XXX, DCXXXX, Development, DXXXXX, Ferritin, HA-Ferritin, HEMAGGLUTINATION, HEMAGGLUTININ, INFLUENZA, inhibition, Nanoparticles, SELF-ASSEMBLING, Vaccine

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Metallic Nanoparticles for Photothermal Therapy

The invention relates to the preparation and application of 20-150nm metallic nanoparticulate vesicles for photothermal anti-cancer therapy. The vesicles comprise metallic nanoparticles covalently bound to a hydrophilic and hydrophobic polymer. The preparation method generally entails dispersing a polymer-bound metallic nanoparticle in an organic...

Published: 7/25/2024 | Inventor(s): Jibin Song, Xiaoyuan (Shawn) Chen

Keywords(s): CB7XXX, Nanoparticle, Nanoparticle-Based, Nanoparticles, Nanoparticulate, phototherapy, Photothermal, Photothermal/Photodynamic, PXXXXX, XGXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology