Search Results - nanoparticle

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Nanoparticle delivery of lung cancer therapeutic

Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in developed countries. Despite the availability of several synergistic, targeted therapy regiments, the 5-year survival rate for NSCLC is only 15%. The poor prognosis of NSCLS is due in part to limitations of current treatments, which do not trigger an immune...

Published: 5/22/2024 | Inventor(s): Dennis Klinman, Takashi Sato (Unable To Locate)

Keywords(s): Immunotherapy, Nanoparticle, Non-small cell lung cancer, NSCLC

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Peptide Hydrogels for Rate-Controlled Delivery of Therapeutics

Abstract: Hydrogels represent an attractive controlled drug-delivery system that have been used in various clinical applications, such as: tissue engineering for wound healing, surgical procedures, pain management, cardiology, and oncology. High-water content of hydrogels confers tissue-like physical properties and the crosslinked fibrillar network...

Published: 4/8/2024 | Inventor(s): Joel Schneider, Stephen Miller, Yuji Yamada, Steven Tau, Julie Hixon, Wenqing Li, Caroline Andrews, Scott Walsh

Keywords(s): DEVICE, IL-7, Nanoparticle, Peptide, Peptide-based Hydrogel, Protein, Schneider, small molecule, T Cell Enhancer, Whole Cell Delivery System

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Immunology

Synthetic Bacterial Nanoparticles as Drug and Vaccine Delivery Vehicles

Abstract: Bacterial spores can be modified to display molecules of interest, including drugs, immunogenic peptides, antibodies and other functional proteins of interest (such as enzymes). The resulting engineered bacterial spores can provide many useful functions such as the treatment of infections, use as an adjuvant for the delivery of vaccines,...

Published: 5/21/2024 | Inventor(s): Kumaran Ramamurthi, I-Lin Wu

Keywords(s): Bacterial Spore, Drug Delivery, Nanoparticle, Ramamurthi, SSHEL, Synthetic Spore Husk-encased Lipid Bilayer, VACCINE DELIVERY

Category(s): TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Inducible Activation Nucleic Acid Hybrid Switch for Conditional Generation of Oligonucleotides

Abstract: Gene therapy research has yielded FDA-approved treatments for an array of diseases. However, challenges facing nucleic-acid based therapeutics include non-specific delivery and degradation of the nanoparticles. NCI investigators have developed a solution to address these challenges in their novel nucleic-based therapy based on the conditional...

Published: 7/29/2024 | Inventor(s): Bruce Shapiro, Paul Zakrevsky

Keywords(s): Conditional Activation, Functional RNA, Gene silencing, In Silico Design, Nanoparticle, Nucleic Acid Therapeutic, RNA, RNA Logic, Shapiro

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

Abstract: The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA and RNA/DNA nanoparticles including multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins....

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Angelica Martins, Mathias Viard

Keywords(s): BREAST CANCER, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Nanoparticle-hydrogel Composite for Nucleic Acid Molecule Delivery

Abstract: Mesothelioma is an aggressive cancer covering anatomic surfaces (e.g. lining of the lungs, heart, abdomen, etc.) that resists multi-modality therapies. Regional recurrence of mesothelioma from residual tumor cells prevents long-term benefits after surgical resection. Furthermore, there is no clinical consensus on intracavitary adjuvants that...

Published: 4/8/2024 | Inventor(s): Joel Schneider, Poulami Majumder, Chuong Hoang, Anand Singh

Keywords(s): Hoang, Hydrogel, Mesothelioma, MicroRNA, Nanoparticle, Schneider, Surface Cancer

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles

Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs. Researchers...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia

Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing

Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes. Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger

Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics

In silico design of RNA nanoparticles

Abstract: RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy,...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Yaroslava Yingling, Luc Jaeger, Isil Severcan, Cody Geary, Eckart Bindewald, Wojciech Kasprzak, Kirill Afonin

Keywords(s): nanobiology, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Co-Transcriptional Assembly of Modified RNA Nanoparticles

Abstract: The National Cancer Institute seeks parties interested in collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications. The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Maria Kireeva, Mikhail Kashlev, Wade Grabow, Luc Jaeger

Keywords(s): Drug Delivery, Nanoparticle, RNA

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

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