Search Results - kirill+afonin

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Programmable and Modular Nucleic Acid Nanoassemblies-based (NAN) Platforms to Regulate Mechanosensitive Activation of T-cells

This technology includes mechanobiological nucleic acid nanoassemblies-based platforms with dynamically controlled efficiency of T-cell activation. T-cells are the central players in adaptive immune response led by a T-cell receptor (TCR) centric machinery. Current T-cell activation strategy (e.g., micron-scale beads) focuses on 2D TCR-agonist biomimetic...

Published: 8/12/2024 | Inventor(s): Kirill Afonin, Erdem Tabdanov, Alexander Zhovmer

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing

Nanoparticles for the targeted treatment of infected cells

Abstract: Current treatments for cancer and viral infection are limited remedies that often suppress cell or viral replication rather than eliminate diseased cells entirely from the body. A further limitation is that these therapies often compromise healthy cells as well, leaving problems of recurrence and side effects. Researchers at developed a novel...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Arti Santhanam, Mathias Viard, Luc Jaeger, Eckart Bindewald

Keywords(s): RNA nanoparticles, SiRNA, viral infections

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Therapeutics

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

Abstract: The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA and RNA/DNA nanoparticles including multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins....

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Angelica Martins, Mathias Viard

Keywords(s): BREAST CANCER, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Nucleic Acid Nanoparticles (NANP) and Methods of Using Same for Controlled Immunomodulation

Abstract: The technology is directed to compositions and methods of designing nucleic acid nanoparticles (NANPs) composed entirely of DNA, RNA, or DNA and RNA to achieve desirable immunostimulation and decrease undesirable effects on the immune system by changing the composition of the NANP. Benefits of the invention include the desirable activation...

Published: 4/8/2024 | Inventor(s): Kirill Afonin, Justin Halman, Marina Dobrovolskaia, Enping Hong

Keywords(s): CANCER, Dobrovolskaia, IMMUNE, Immunomodulation, Inflammation, Nucleic Acid Nanoparticle

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics

Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles

Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs. Researchers...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia

Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

Nucleic Acid Nanoparticles for Triggering RNA Interference

Abstract: RNA interference (RNAi) is a naturally occurring cellular post-transcriptional gene regulation process that utilizes small double-stranded RNAs to trigger and guide gene silencing. By introducing synthetic RNA duplexes called small-interfering RNAs (siRNAs), we can harness the RNAi machinery for therapeutic gene control and the treatment of...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Kirill Afonin

Keywords(s): nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics

In silico design of RNA nanoparticles

Abstract: RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy,...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Yaroslava Yingling, Luc Jaeger, Isil Severcan, Cody Geary, Eckart Bindewald, Wojciech Kasprzak, Kirill Afonin

Keywords(s): nanobiology, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Co-Transcriptional Assembly of Modified RNA Nanoparticles

Abstract: The National Cancer Institute seeks parties interested in collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications. The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Maria Kireeva, Mikhail Kashlev, Wade Grabow, Luc Jaeger

Keywords(s): Drug Delivery, Nanoparticle, RNA

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

RNA/DNA Nanoparticles as Cancer Therapeutics

Abstract: The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine. RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Eckart Bindewald, Kirill Afonin, Lorena Parlea

Keywords(s): Gene silencing, nanobiology, RNAi, Shapiro

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology