Search Results - eckart+bindewald

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Nanoparticles for the targeted treatment of infected cells

Abstract: Current treatments for cancer and viral infection are limited remedies that often suppress cell or viral replication rather than eliminate diseased cells entirely from the body. A further limitation is that these therapies often compromise healthy cells as well, leaving problems of recurrence and side effects. Researchers at developed a novel...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Arti Santhanam, Mathias Viard, Luc Jaeger, Eckart Bindewald

Keywords(s): RNA nanoparticles, SiRNA, viral infections

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Therapeutics

Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles

Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs. Researchers...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia

Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

In silico design of RNA nanoparticles

Abstract: RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy,...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Yaroslava Yingling, Luc Jaeger, Isil Severcan, Cody Geary, Eckart Bindewald, Wojciech Kasprzak, Kirill Afonin

Keywords(s): nanobiology, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

RNA/DNA Nanoparticles as Cancer Therapeutics

Abstract: The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine. RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Eckart Bindewald, Kirill Afonin, Lorena Parlea

Keywords(s): Gene silencing, nanobiology, RNAi, Shapiro

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology