Search Results - gene+silencing

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Inducible Activation Nucleic Acid Hybrid Switch for Conditional Generation of Oligonucleotides

Abstract: Gene therapy research has yielded FDA-approved treatments for an array of diseases. However, challenges facing nucleic-acid based therapeutics include non-specific delivery and degradation of the nanoparticles. NCI investigators have developed a solution to address these challenges in their novel nucleic-based therapy based on the conditional...

Published: 7/29/2024 | Inventor(s): Bruce Shapiro, Paul Zakrevsky

Keywords(s): Conditional Activation, Functional RNA, Gene silencing, In Silico Design, Nanoparticle, Nucleic Acid Therapeutic, RNA, RNA Logic, Shapiro

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing

Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes. Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger

Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics

RNA/DNA Nanoparticles as Cancer Therapeutics

Abstract: The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine. RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Eckart Bindewald, Kirill Afonin, Lorena Parlea

Keywords(s): Gene silencing, nanobiology, RNAi, Shapiro

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology