Search Results - luc+jaeger

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Nanoparticles for the targeted treatment of infected cells

Abstract: Current treatments for cancer and viral infection are limited remedies that often suppress cell or viral replication rather than eliminate diseased cells entirely from the body. A further limitation is that these therapies often compromise healthy cells as well, leaving problems of recurrence and side effects. Researchers at developed a novel...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Arti Santhanam, Mathias Viard, Luc Jaeger, Eckart Bindewald

Keywords(s): RNA nanoparticles, SiRNA, viral infections

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Therapeutics

siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing

Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes. Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger

Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics

In silico design of RNA nanoparticles

Abstract: RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy,...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Yaroslava Yingling, Luc Jaeger, Isil Severcan, Cody Geary, Eckart Bindewald, Wojciech Kasprzak, Kirill Afonin

Keywords(s): nanobiology, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Co-Transcriptional Assembly of Modified RNA Nanoparticles

Abstract: The National Cancer Institute seeks parties interested in collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications. The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Maria Kireeva, Mikhail Kashlev, Wade Grabow, Luc Jaeger

Keywords(s): Drug Delivery, Nanoparticle, RNA

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology