Search Results - mathias+viard

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Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery

Abstract: The invention relates to novel lipid-based nanoparticles (liposomes) for use in targeted, on demand and on site drug delivery. The particles include a wall surrounding a cavity, wherein the wall is comprised of: A lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine...

Published: 4/8/2024 | Inventor(s): Anu Puri, Robert Blumenthal, Amit Joshi, Darayash Tata, Mathias Viard

Keywords(s): Combination Therapy, Delivery Agent, Infections (bacteria and viruses), Lipid nanoparticle, liposome, On-demand Drug Release, photoactivation, therapeutic delivery

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Dermatology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Design and Biological Activity of Novel Stealth Polymeric Lipid Nanoparticles for Enhanced Delivery of Hydrophobic Photodynamic Therapy Drugs

Abstract: Nanoparticles such as lipid-based nanoparticles (LNPs) represent a relatively new era of targeted drug delivery systems wherein these biocompatible particles can carry the drug(s) of interest to a specific tumor site. The new generation of nanoparticles, known as stealth nanoparticles, are engineered to have a coating of polyethylene glycol...

Published: 8/14/2024 | Inventor(s): Anu Puri, Mathias Viard

Keywords(s): Lipid-based Nanoparticle, LPN, PDT, Photodynamic Drug, Puri, Stealth Nanoparticle

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Nanoparticles for the targeted treatment of infected cells

Abstract: Current treatments for cancer and viral infection are limited remedies that often suppress cell or viral replication rather than eliminate diseased cells entirely from the body. A further limitation is that these therapies often compromise healthy cells as well, leaving problems of recurrence and side effects. Researchers at developed a novel...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Arti Santhanam, Mathias Viard, Luc Jaeger, Eckart Bindewald

Keywords(s): RNA nanoparticles, SiRNA, viral infections

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Therapeutics

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

Abstract: The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA and RNA/DNA nanoparticles including multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins....

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Angelica Martins, Mathias Viard

Keywords(s): BREAST CANCER, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles

Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs. Researchers...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia

Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

Nucleic Acid Nanoparticles for Triggering RNA Interference

Abstract: RNA interference (RNAi) is a naturally occurring cellular post-transcriptional gene regulation process that utilizes small double-stranded RNAs to trigger and guide gene silencing. By introducing synthetic RNA duplexes called small-interfering RNAs (siRNAs), we can harness the RNAi machinery for therapeutic gene control and the treatment of...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Kirill Afonin

Keywords(s): nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics

RNA/DNA Nanoparticles as Cancer Therapeutics

Abstract: The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine. RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Mathias Viard, Eckart Bindewald, Kirill Afonin, Lorena Parlea

Keywords(s): Gene silencing, nanobiology, RNAi, Shapiro

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology