Search Results - drug+delivery

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Polymeric Delivery Platform for Therapeutics

Abstract: Drug delivery technologies have long claimed the ability to selectively deliver therapeutic cargo to target cells. Despite advances in nanomedicine and drug delivery systems, there are no targeted nanoscale drug delivery technologies on the market. Thus, there is still tremendous potential in improved therapeutic efficacy when targeted drug...

Published: 4/8/2024 | Inventor(s): David Stevens, Stephan Stern, Scott McNeil, Marina Dobrovolskaia

Keywords(s): Drug Delivery, Immunotherapy, Scavenger Receptor A1, SR-A1

Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Synthetic Bacterial Nanoparticles as Drug and Vaccine Delivery Vehicles

Abstract: Bacterial spores can be modified to display molecules of interest, including drugs, immunogenic peptides, antibodies and other functional proteins of interest (such as enzymes). The resulting engineered bacterial spores can provide many useful functions such as the treatment of infections, use as an adjuvant for the delivery of vaccines,...

Published: 5/21/2024 | Inventor(s): Kumaran Ramamurthi, I-Lin Wu

Keywords(s): Bacterial Spore, Drug Delivery, Nanoparticle, Ramamurthi, SSHEL, Synthetic Spore Husk-encased Lipid Bilayer, VACCINE DELIVERY

Category(s): TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants

Abstract: Gel materials, particularly hydrogels, typically lose their mechanical strength and stiffness as they swell. This property limits their use in both biological (e.g., cartilage and ECM repair) and non-biological (e.g., sealant) applications. Innovative materials in both medical and non-medical application areas are sorely needed. Recent innovations...

Published: 4/8/2024 | Inventor(s): Ferenc Horkay, Peter Basser

Keywords(s): Basser, Cartilage, Composite, Drug Delivery, Gel, Horkay, Hydrogels, IMPLANTS, MATRIX, polymer, sealants, Tissue, Tissue Repair

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Materials Available, TherapeuticArea > Dermatology

Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles

Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs. Researchers...

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia

Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

Co-Transcriptional Assembly of Modified RNA Nanoparticles

Abstract: The National Cancer Institute seeks parties interested in collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications. The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method...

Published: 8/13/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Maria Kireeva, Mikhail Kashlev, Wade Grabow, Luc Jaeger

Keywords(s): Drug Delivery, Nanoparticle, RNA

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Self-Assembling Nanoparticles Composed of Transmembrane Peptides and Their Application for Specific Intra-Tumor Delivery of Anti-Cancer Drugs

Abstract: Peptides corresponding to transmembrane domains of a number of integral proteins were discovered to spontaneously self-assemble in aqueous solutions into stable and remarkably uniform nanoparticles. Researchers at the NCI’s Cancer and Inflammation Program have developed fully synthetic, peptide-based, virus-like nanoparticles capable...

Published: 4/8/2024 | Inventor(s): Nadya Tarasova, Sergey Tarasov, Christopher Michejda

Keywords(s): Drug Delivery, GPCR, Hydrophobic Agent, Nanoparticle, Peptide-based Nanoparticle, Synthetic Peptide, Tarasova, VIRUS-LIKE

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics

Intranasal delivery is a simple, inexpensive and needle-free route for administration of vaccines and therapeutics. This intranasal delivery technology, developed with Creare LLC., includes low-cost, disposable drug cartridges (DDCs) that mate with a durable hand-held device. The rechargeable-battery-powered device transmits ultrasonic energy to the...

Published: 7/25/2024 | Inventor(s): James Barry, Nabil Elkouh, Mark Bagley, Darin Knaus, Robert Trabka, Eric Friets, James Norris, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, AB3XXX, AB4XXX, Able, ABXXXX, AC1XXX, ACXXXX, AEROSOL, AEROSOL-GENERATING, AEROSOLIZATION, Aerosolized, AEROSOLS, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, CARTRIDGE, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, Chamber, COOLING, DB1XXX, DB2XXX, DB3XXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, Delivery, DEVICE, Devices, Disposable, DRUG, Drug Delivery, DXXXXX, FUNGAL, HAND, Having, INSERT, Intranasal, Methods, NASAL, NEBULIZER, NIOSH-PRL, OID-NCIRD-DVD, PLATFORM, Platforms, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, System, SYSTEMS, therapeutic, therapeutic delivery, Vaccine, VACCINE DELIVERY, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, viral, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YCXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Medical Devices, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology

Intra-bone Drug Delivery Device and Method

The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods...

Published: 7/25/2024 | Inventor(s): Robert Hoyt, Timothy Hunt, Randall Clevenger, Omer Aras, Richard Childs, Jeremy Pantin

Keywords(s): AB2XXX, AB3FXX, AB3GXX, AB3XXX, ABXXXX, AXXXXX, DEVICE, Devices, Drug Delivery, Intrabone, PRESSURE, PRESSURE SENSOR, Pressure-mediated

Category(s): Collaboration Sought > Collaboration