Search Results - richard+childs

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Blocking CD38 using Daratumumab F(ab)2 to Protect Natural Killer Cells from Daratumumab-induced Apoptosis and Cell Death for the Treatment of Multiple Myeloma

This technology includes the method of blocking CD38 in expanded natural killer (NK) cell therapy in combination with daratumumab in patients with multiple myeloma. Our in vitro studies have already confirmed the addition of NK cells to myeloma cells that have been exposed to daratumumab enhances myeloma killing compared to single agent treatment. Studies...

Published: 8/12/2024 | Inventor(s): Richard Childs, Jorge Luis Espinoza-Calderon, Maria Berg

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Human Cell Lines, TherapeuticArea > Oncology

Highly Efficient Gene Transfer into Primary and Expanded Human Natural Killer Cells by Lentiviral Transduction for Cancer Therapy

This technology includes an efficient lentiviral vector-based method for gene transfer into NK cells and demonstrates a stable and long-term robust expression of transgenes for the treatment of cancer. High gene transfer rates into primary cells being transduced and the ability to produce high titers of virus particles for large-scale transduction of...

Published: 8/12/2024 | Inventor(s): Richard Childs, Dhanalakshmi (Donna) Chinnasamy

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, TherapeuticArea > Oncology

Genetic Manipulation of Natural Killer Cells to Express c-MPL Growth Factor Receptor as a Therapy for Cancer

This technology includes genetic manipulation of natural killer (NK) cells to express thrombopoietin receptor (c-MPL) growth factor receptor as strategy to augment NK cell proliferation and anti-tumor immunity. Many investigational adoptive immunotherapy regimens utilizing NK cells require the administration of IL-2 or IL-15 cytokines to support the...

Published: 8/12/2024 | Inventor(s): David Allan, Richard Childs

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Oncology

Human Monoclonal Antibodies to Generate Chimeric Antigen Receptor (CAR) T-cells to Treat Patients with Advanced Clear Cell Renal Cell Carcinoma (ccRCC).

This technology includes six human monoclonal antibodies (mAbs) that target tumor antigens derived from the CT-RCC HERV-E (human endogenous retrovirus type E) to generate Chimeric Antigen Receptor (CAR) T cells to treat patients with advanced clear cell renal cell carcinoma (ccRCC). These mAbs were identified from Adagene Inc’s human antibody...

Published: 8/12/2024 | Inventor(s): Richard Childs, Long Chen, Elena Cherkasova

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies, TherapeuticArea > Oncology

Epstein-Barr Virus (EBV)-feeder Cell Line

This technology includes irradiated Epstein-Barr virus-transformed lymphoblastoid cell lines (EBV-LCL) as feeder cells for the ex vivo expansion of natural killer (NK) cells. EBV-LCL feeder cells, altered by radiation to prevent uncontrolled growth, provide a supportive environment for NK cells to multiply effectively. This method addresses the challenge...

Published: 8/12/2024 | Inventor(s): Richard Childs

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology

Blocking CD38 using Protein G Complexed Daratumumab Antibodies (PGDARA) to Protect Natural Killer Cells from Daratumumab-induced Apoptosis and Cell Death for the Treatment of Multiple Myeloma

Published: 8/12/2024 | Inventor(s): Richard Childs, Jorge Luis Espinoza-Calderon, Maria Berg

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Human Cell Lines, TherapeuticArea > Oncology

Intra-bone Drug Delivery Device and Method

The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods...

Published: 7/25/2024 | Inventor(s): Robert Hoyt, Timothy Hunt, Randall Clevenger, Omer Aras, Richard Childs, Jeremy Pantin

Keywords(s): AB2XXX, AB3FXX, AB3GXX, AB3XXX, ABXXXX, AXXXXX, DEVICE, Devices, Drug Delivery, Intrabone, PRESSURE, PRESSURE SENSOR, Pressure-mediated

Category(s): Collaboration Sought > Collaboration

Device for Selective Partitioning of Frozen Cellular Products

Cryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation....

Published: 7/25/2024 | Inventor(s): Sumithira Vasu, Richard Childs

Keywords(s): AC3XXX, ACXXXX, AE1BXX, AE1XXX, AEXXXX, AXXXXX, BAG, Cryopreserved, DEVICE, Method, Patent Category - Mech/Elect/Soft, SAMPLE, STERILE, Umbilical Cord Blood, VCXXXX, VEXXXX, VPXXXX, WBXXXX, WHXXXX, WIXXXX, WJXXXX, WMXXXX, XDXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Materials Available, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology, Application > Medical Devices, Application > Research Materials, Application > Diagnostics

Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7

A highly efficient method to genetically modify natural killer (NK) cells to induce expression of high affinity CD16 (HA-CD16) through mRNA electroporation, to potentiate NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). ADCC is mediated by CD16+ NK cells following adoptive NK cell transfer, but most humans express CD16 which has a relatively...

Published: 7/25/2024 | Inventor(s): Mattias Carlsten, Richard Childs

Keywords(s): ADCC, antibodies, ANTIBODY, CBXXXX, CD16, ex vivo, Listed LPM Vathyam as of 4/15/2015, monoclonal, NK, NK Cells, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, TRANSFECTION, TUMORS, VCXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Enriched Natural Killer Cells for Adoptive Infusion Cancer Therapy

Immuno-therapy has taken a lead among the new cancer therapeutic approaches. It is one of the most promising new therapeutic approaches that exploit the innate immune mechanism of an individual to fight against a certain disease. Natural killer (NK) cells are a form of cytotoxic lymphocytes which constitute a major portion of the innate immune system....

Published: 7/25/2024 | Inventor(s): Richard Childs

Keywords(s): 47 XYY syndrome, BBXXXX, CB6XXX, CBXXXX, CXXXXX, Double Y

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics

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