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Chimeric Antigen Receptor (CAR) that Targets Chemokine Receptor CCR4 and its Use in Treating Cancer

Abstract: The chemokine receptor, CCR4 is a seven transmembrane G protein-coupled cell surface receptor molecule with selective expression on cells of the hematopoietic system. In adult T cell leukemia (ATL), the cell-surface expression of CCR4 on leukemic cells has been found to be nearly universal. Therefore, a CCR4-directed chimeric antigen receptor...

Published: 4/8/2024 | Inventor(s): Liyanage Perera, Thomas Waldmann

Keywords(s): Adult T Cell Leukemia, ALLOGENIC, ATL, CCR4, CD3+, Chemokine Receptor 4, Immunotherapy, Lymphoid Malignancy, mRNA, natural killer cell, NK, Perera, solid tumor, T cell

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7

A highly efficient method to genetically modify natural killer (NK) cells to induce expression of high affinity CD16 (HA-CD16) through mRNA electroporation, to potentiate NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). ADCC is mediated by CD16+ NK cells following adoptive NK cell transfer, but most humans express CD16 which has a relatively...

Published: 7/25/2024 | Inventor(s): Mattias Carlsten, Richard Childs

Keywords(s): ADCC, antibodies, ANTIBODY, CBXXXX, CD16, ex vivo, Listed LPM Vathyam as of 4/15/2015, monoclonal, NK, NK Cells, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, TRANSFECTION, TUMORS, VCXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology