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Bioplatform to Identify and Characterize Pathogens and Therapies against Tuberculosis and Other Granulomatous Diseases.
Treatment for human tuberculosis (TB) and other granulomatous diseases would benefit from high- throughput screening (HTS)-compatible platform replicating physiological conditions in hallmark granuloma lesions. However, currently available screening platforms and 2-D and 3-D cell culture systems lack throughput and key features, and relevant microenvironments...
Published: 5/9/2025
|
Inventor(s):
Suraj Sable
,
James Posey
,
Wen Li
,
Allison Kline
Keywords(s):
Category(s):
Application > Therapeutics
,
Application > Research Materials
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
Peptide Hydrogels for Rate-Controlled Delivery of Therapeutics
Abstract: Hydrogels represent an attractive controlled drug-delivery system that have been used in various clinical applications, such as: tissue engineering for wound healing, surgical procedures, pain management, cardiology, and oncology. High-water content of hydrogels confers tissue-like physical properties and the crosslinked fibrillar network...
Published: 4/22/2025
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Inventor(s):
Joel Schneider
,
Stephen Miller
,
Yuji Yamada
,
Steven Tau
,
Julie Hixon
,
Wenqing Li
,
Caroline Andrews
,
Scott Walsh
Keywords(s):
DEVICE
,
IL-7
,
Nanoparticle
,
Peptide
,
Peptide-based Hydrogel
,
Protein
,
Schneider
,
small molecule
,
T Cell Enhancer
,
Whole Cell Delivery System
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
,
TherapeuticArea > Immunology
IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)
Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment. The...
Published: 4/23/2025
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Inventor(s):
Scott Durum
,
Julie Hixon
,
Wenqing Li
,
Scotch Walsh
,
Lila Kashi
Keywords(s):
Acute lymphoblastic leukemia (ALL)
,
ANTIBODY
,
Antibody-Dependent Cellular Cytotoxicity (ADCC)
,
Autoimmunity
,
CANCER
,
DIABETES
,
Durum
,
Interleukin-7 receptor-α (IL-7Rα)
,
Multiple sclerosis
,
personalized medicine
,
Targeted therapy
,
THERAPY
,
TRANSPLANTATION
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
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