Search Results - resonance

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Novel Codon-Optimized MUT Gene Therapeutic for Methylmalonic Acidemia (MMA)

Methylmalonic Acidemia (MMA) is a metabolic disorder characterized by increased acidity in the blood and tissues due to toxic accumulation of protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. A significant portion of MMA cases stem from a deficiency in a key mitochondrial enzyme, methylmalonyl-CoA mutase (MUT),...

Published: 7/25/2024 | Inventor(s): Colin Shea, Ciprian Crainiceanu, Elizabeth Sweeney, Russell Shinohara, Arthur Goldsmith, Daniel Reich

Keywords(s): Automatic, brain, Detection, IMAGING, Incidence, Lesion, Listed LPM Shmilovich as of 4/15/2015, Longitudinal, Magnetic, MULTIMODALITY, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resonance, software, SuBLIME:, VPXXXX, WJXXXX, XEXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease

OASIS: Automated brain lesion detection using cross-sectional multimodal magnetic resonance imaging

This invention is a novel statistical method for automatically detecting lesions in cross-sectional brain magnetic resonance imaging (MRI) studies. OASIS uses multimodal MRI from one image acquisition session and produces voxel-level probability maps of the brain that quantifies the likelihood that each voxel is part of a lesion. Binary lesion segmentations...

Published: 7/25/2024 | Inventor(s): Ciprian Crainiceanu, Elizabeth Sweeney, Russell Shinohara, Arthur Goldsmith, Navid Shiee, Dzung Pham, Daniel Reich

Keywords(s): Automated, brain, CNRM CRADA, Cross, Detection, IMAGING, Lesion, Listed LPM Shmilovich as of 4/15/2015, Magnetic, MULTIMODALITY, OASIS:, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resonance, SECTIONAL, software, VEXXXX, WBXXXX, WIXXXX, XFXXXX

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, Application > Research Materials, Application > Software / Apps, Application > Diagnostics, Application > Non-Medical Devices, TherapeuticArea > Neurology

Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast

The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod...

Published: 7/25/2024 | Inventor(s): Jinhao Gao, Zhenghuan Zhao, Xiaoyuan (Shawn) Chen

Keywords(s): Agents, CA2CXX, Contrast, High-Performance, IMAGING, IRON, Magnetic, Nanoparticles, Non-spherical, OXIDE, PXXXXX, Resonance, T2, VCXXXX, VDXXXX, WBXXXX, XFXXXX, XGXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

Signal-to-Noise Enhancement in Imaging Applications Using a Time-Series of Images

The invention offered for licensing relates to the field of imaging and specifically to the field of medical imaging. The apparatus and method of the invention provide for noise reduction in imaging applications that use a time-series of images. In one embodiment of the invention, a time-series of images is acquired using a same imaging protocol of...

Published: 7/25/2024 | Inventor(s): Vinay Pai, Han Wen

Keywords(s): Acquisitions, analysis, COMBINED, COMPONENT, ENHANCEMENT, IA4BXX, IA4XXX, IAXXXX, IMAGING, INTENSITY, IXXXXX, LOW, Magnetic, Maximal, Method, Patent Category - Mech/Elect/Soft, PCA, PRINCIPAL, PROJECTION, Resonance, Signal, Signal-to-Noise, TEMPORAL, tMIP

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Microfabricated Particles Useful as MRI Contrast Agents

MRI contrast agents are versatile yet lack the sensitivity and multiplexing capabilities of optical agents. Available for licensing is an invention pertaining to microfabricated structures that can be used as MRI contrast agents with enhanced functionality or as micro-RFID (radio-frequency identification) tags. The microstructures can be engineered...

Published: 7/19/2024 | Inventor(s): Stephen Dodd, Alan Koretsky, John Moreland, Gary Zabow

Keywords(s): AA1XXX, AA3CXX, AA3XXX, AAXXXX, AB3CXX, AB3XXX, ABXXXX, AXXXXX, IMAGING, imaging agent, ImagingMRI, Magnetic, Magnetic Resonance, Microstructures, MRI, Resonance, STENT, Stents, SYSTEMS

Category(s): Collaboration Sought > Collaboration

Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI

Available for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis. Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing...

Published: 4/8/2024 | Inventor(s): Anthony Aletras, Kathleen Ward, Robert Balaban

Keywords(s): AA3AXX, AA3B1X, AA3BXX, AA3XXX, AAXXXX, AXXXXX, Contrast, CSalata, ENHANCING, IMAGES, IMAGING, Magnetic, Method, Patent Category - Mech/Elect/Soft, PRODUCED, Resonance

Category(s): Collaboration Sought > Licensing

Software for Fully Automating Myocardial Perfusion Quantification

Software is has been developed and available for licensing that fully automates image processing for the quantification of myocardial blood flow (MBF) pixel maps from firstpass contrast-enhanced cardiac magnetic resonance (CMR) perfusion images. The system removes the need for laborious manual quantitative CMR perfusion pixel map processing and can...

Published: 7/29/2024 | Inventor(s): Andrew Arai, Matthew Jacobs, Mitchel Benovoy, Li-Yueh Hsu

Keywords(s): Automated, Cardiac, First-pass, FULLY, IMAGING, Magnetic, MYOCARDIAL, Perfusion, QUANTIFICATION, Resonance, System, VDXXXX, WIXXXX, XJXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, Application > Software / Apps

Local Magnetization Spoiling Using a Gradient Insert for Reducing the Field of View in Magnetic Resonance Imaging

The present invention provides a method and device for eliminating alias artifacts encountered in MRI when the field of view is made smaller than the subject being imaged. Significant advantages accrue from reducing the field of view to a smaller region of interest. These include reduced imaging time, increased spatial and temporal resolution, and less...

Published: 7/25/2024 | Inventor(s): Steven Wolff, Robert Balaban, Han Wen, David Wiesler

Keywords(s): AA3B1X, AA3BXX, AA3XXX, AAXXXX, ALL DISEASES, AXXXXX, CSalata, diagnostic, Field, GENERAL MEDICINE, GRADIENT, IMAGING, INSERT, LOCAL, Magnetic, Magnetization, MRI, REDUCING, Resonance, SPOILING, VIEW

Category(s): Collaboration Sought > Licensing