Search Results - lesion

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Novel Codon-Optimized MUT Gene Therapeutic for Methylmalonic Acidemia (MMA)

Methylmalonic Acidemia (MMA) is a metabolic disorder characterized by increased acidity in the blood and tissues due to toxic accumulation of protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. A significant portion of MMA cases stem from a deficiency in a key mitochondrial enzyme, methylmalonyl-CoA mutase (MUT),...

Published: 7/25/2024 | Inventor(s): Colin Shea, Ciprian Crainiceanu, Elizabeth Sweeney, Russell Shinohara, Arthur Goldsmith, Daniel Reich

Keywords(s): Automatic, brain, Detection, IMAGING, Incidence, Lesion, Listed LPM Shmilovich as of 4/15/2015, Longitudinal, Magnetic, MULTIMODALITY, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resonance, software, SuBLIME:, VPXXXX, WJXXXX, XEXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease

OASIS: Automated brain lesion detection using cross-sectional multimodal magnetic resonance imaging

This invention is a novel statistical method for automatically detecting lesions in cross-sectional brain magnetic resonance imaging (MRI) studies. OASIS uses multimodal MRI from one image acquisition session and produces voxel-level probability maps of the brain that quantifies the likelihood that each voxel is part of a lesion. Binary lesion segmentations...

Published: 7/25/2024 | Inventor(s): Ciprian Crainiceanu, Elizabeth Sweeney, Russell Shinohara, Arthur Goldsmith, Navid Shiee, Dzung Pham, Daniel Reich

Keywords(s): Automated, brain, CNRM CRADA, Cross, Detection, IMAGING, Lesion, Listed LPM Shmilovich as of 4/15/2015, Magnetic, MULTIMODALITY, OASIS:, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resonance, SECTIONAL, software, VEXXXX, WBXXXX, WIXXXX, XFXXXX

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, Application > Research Materials, Application > Software / Apps, Application > Diagnostics, Application > Non-Medical Devices, TherapeuticArea > Neurology