Search Results - tempol

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Tempol as a Therapeutic to Treat Covid-19 Via Inhibition of Viral Replication

Abstract: Despite several partially effective prophylactic vaccines for SARS-CoV-2 exist, patients worldwide still succumb to COVID-19. New therapeutics to treat this disease are still needed. Upon host invasion, a critical step in the pathogenesis of COVID-19 is intracellular replication of SARS-CoV-2 before viral particles invade nearby healthy cells....

Published: 4/8/2024 | Inventor(s): Tracey Rouault, William Linehan, Nunziata Maio

Keywords(s): ANTIVIRAL, COVID-19, RdRP Inhibitor, RNA-dependent RNA Polymerase inhibitor, Rouault, SARS-CoV-2, Tempol

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology

Tempol: A Commercially-Available Nitroxide as a Cancer Therapeutic

Abstract: The National Cancer Institute's Urologic Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of Tempol to target HIF-2a in cancer. Elevated HIF-2a is associated with clear cell kidney cancer characterized by mutation of the...

Published: 4/8/2024 | Inventor(s): William Linehan, Tracey Rouault, James Mitchell, Murali Cherukuri

Keywords(s): clear cell, HIF-2, kidney cancer, NITROXIDE, Tempol

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics