Search Results - signaling

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Novel ACRV1/ALK2 Inhibitors and Methods for Inhibiting BMP Signaling for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

This technology includes the identification and use of novel ACRV1/ALK2 inhibitors for the treatment of fibrodysplasia ossificans progressiva (FOP), an autosomal-dominant rare disease that affects one person in every 1-2 million. FOP is characterized by malformation of the great (big) toes during embryonic development and by progressive heterotopic...

Published: 7/25/2024 | Inventor(s): Jian-kang Jiang, Khalida Shamim, Philip Sanderson, Wei Zheng, Xiuli Huang, Gregory Tawa, Asaf Alimardanov, Arthur Lee, Junfeng Huang, Wenwei Huang

Keywords(s): ALK2, BMP, INHIBITING, Inhibitors, Methods, Novel, SIGNALING, VGXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, Application > Research Materials

Antagonists of Hyaluronan Signaling for Treatment of Airway Diseases

Airway diseases, such as Asthma and Chronic Obstructive Pulmonary Disease (COPD), constitute a major health burden worldwide. It is estimated, for example, that nearly 15.0% of the adult population in the US are affected with such diseases, and the economic cost burden is over $23 billion annually. Unfortunately, the current options for treatment of...

Published: 7/25/2024 | Inventor(s): John Hollingsworth, Bryan Toole, Jian Liu, Stavros Garantziotis

Keywords(s): AIRWAY, ANTAGONISTS, hyaluronan, Hyperresponsiveness, IB4XXX, IBXXXX, Inflammation, IXXXXX, SIGNALING, treatment, VPXXXX, WKXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Dental, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Pulmonology

Transgenic Mice with Conditionally-Enhanced Bone Morphogen Protein (BMP) Signaling: A Model for Human Bone Diseases

This technology relates to novel animal models of several human bone diseases that have been linked to enhanced BMP signaling. More specifically, this mouse model expresses a mutant receptor for BMP, known as Alk2 that is always actively signaling. This receptor is under the control of the Cre-loxP system, which allows control of expression of the...

Published: 7/25/2024 | Inventor(s): Manas Ray, Gregory Scott, Yuji Mishina

Keywords(s): BAXXXX, BMP:, Bone, Craniosynostosis, Disease, Enhanced, Expressing, Fibrodysplasia ossificans progressiva, Human, IDXXXX, IXXXXX, Model, MORPHOGENETIC, Mouse, MULTIPLE MYELOMA, Protein, SIGNALING

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Diagnostics, Application > Research Materials