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Transgenic Mice with Conditionally-Enhanced Bone Morphogen Protein (BMP) Signaling: A Model for Human Bone Diseases

This technology relates to novel animal models of several human bone diseases that have been linked to enhanced BMP signaling. More specifically, this mouse model expresses a mutant receptor for BMP, known as Alk2 that is always actively signaling. This receptor is under the control of the Cre-loxP system, which allows control of expression of the...

Published: 7/25/2024 | Inventor(s): Manas Ray, Gregory Scott, Yuji Mishina

Keywords(s): BAXXXX, BMP:, Bone, Craniosynostosis, Disease, Enhanced, Expressing, Fibrodysplasia ossificans progressiva, Human, IDXXXX, IXXXXX, Model, MORPHOGENETIC, Mouse, MULTIPLE MYELOMA, Protein, SIGNALING

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Diagnostics, Application > Research Materials