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Development of a Transferrable Norwalk Virus Epitope and Detector Monoclonal Antibody

Noroviruses are now recognized as the major cause of non-bacterial gastroenteritis in all age groups, and efforts are underway to develop an effective vaccine. The lack of a robust cell culture system for human noroviruses has complicated vaccine development. Hence, norovirus virus like particles (VLPs) have played an important role in the understanding...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Karin Bok, Carlos Sandoval-Jaime, Eugenio Abente, Gabriel Parra Gonzalez, Lisbeth Kim Green

Keywords(s): ANTIBODY, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DETECTOR, DetectorMonoclonal, Development, DEXXXX, DXXXXX, Epitope, Listed LPM Fenn as of 4/15/2015, monoclonal, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Transferrable, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Infectious Disease

Monoclonal Antibodies that Neutralize Norovirus

Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This technology relates to...

Published: 7/25/2024 | Inventor(s): Karin Bok, Stanislav Sosnovtsev, Lisbeth Kim Green, Robert Purcell, Zhaochun Chen

Keywords(s): antibodies, chimeric, Chimpanzee/Human, DB4BXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, Listed LPM Fenn as of 4/15/2015, monoclonal, Neutralize, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, That, virus, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, ResearchProducts > Antibodies