Search Results - virus-like+particles

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Method for Targeted Therapeutic Delivery of Proteins into Cells

Abstract: Current methods to deliver proteins into cells (e.g., using retrovirus, DNA transfection, protein transduction, microinjection, complexing the protein with lipids, etc.) have many shortcomings, such as lack of target specificity toxicity, or unwanted random integration into the host chromosome. Protein transduction is an emerging technology...

Published: 4/8/2024 | Inventor(s): Deb Chatterjee, Stanislaw Kaczmarczyk

Keywords(s): virus-like particles, VLP

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices

Virus-Like Particles That Can Deliver Proteins and RNA

Abstract: The National Cancer Institute's Protein Expression Laboratory seeks parties interested in licensing the novel delivery of RNA to mammalian cells using virus-like particles. Current methods of delivering proteins or RNA to mammalian cells are limited by a lack of target specificity and toxicity, among other shortcomings. NCI researchers have...

Published: 4/8/2024 | Inventor(s): Stanislaw Kaczmarczyk, Deb Chatterjee

Keywords(s): antibody synthesis, Protein Expression, RNA delivery, virus-like particles

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Zika Virus Vaccines

Zika virus (ZIKV) is a flavivirus transmitted by mosquitos that is strongly linked to neurological complications including Guillain-Barré syndrome, meningoencephalitis, and microcephaly. The association between active ZIKV infection during pregnancy and microcephaly and intrauterine growth retardation in the fetus has been confirmed in murine models...

Published: 7/25/2024 | Inventor(s): John Mascola, Wing-pui Kong, Eun Yang, Wei Shi, Theodore Pierson, Leda Castilho, Kimberly Dowd, Lingshu Wang, Christina Demaso, Rebecca Pelc, Adrian Creanga, Julie Ledgerwood, Sebastian Ramesch, Barney Graham

Keywords(s): Chimera, DC5BXX, GENE-BASED, JAPANESE ENCEPHALITIS VIRUS, vaccines, virus-like particles, VLP, Zika

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease