Search Results - opsonophagocytosis

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This invention aims to bolster the human body's own mechanisms to fight infection by enhancing an innate immune response, opsonophagocytosis. The specific 24 amino acid sequence (P4) acts as a polymorphonuclear cell activator. P4 can be administered in vivo along with a disease's specific antibody to enhance systemic bacterial clearance, thus leading...

Published: 7/25/2024 | Inventor(s): GowriSankar Rajam, Sandra Steiner, George Carlone, Nikkol Atwell-Melnick Melnick, Jacquelyn Sampson, Joseph Martinez, Joseph Caba, Edwin Ades

Keywords(s): ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC1XXX, DC4XXX, DCXXXX, DXXXXX, ENHANCING, Epitopes, FUNCTIONAL, Listed LPM Surabian as of 4/15/2015, Methods, OID-NCIRD-DBD, Opsonophagocytosis, PATHOGEN, PNEUMONIAE, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PsaA, RESPONSE, Streptococcus, THEREOF, USES

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Monoclonal Antibodies That React With the Capsule of Bacillus anthracis

Bacillus anthracis is the causative agent of anthrax and is surrounded by a polypeptide capsule of poly-gamma-D-glutamic acid (gammaDPGA). gammaDPGA is poorly immunogenic and has antiphagocytic properties. The bacterial capsule is essential for virulence. Antibodies to the capsule have been shown to enhance phagocytosis and killing of encapsulated...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Rachel Schneerson, Joanna Kubler-kielb, Lily Zhongdong Dai, Zhaochun Chen

Keywords(s): Anthracis, Anthrax, antibodies, Autoimmune polyendocrinopathy syndrome, type 1, Bacillus, Capsule, chimeric, Chimpanzee/Human, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, KILL, monoclonal, Opsonophagocytosis, ORGANISM, Patent Category - Biotechnology, PGA 1, PGA 2, REACT, Schmidt syndrome, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease