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Monoclonal Antibodies That React With the Capsule of Bacillus anthracis

Bacillus anthracis is the causative agent of anthrax and is surrounded by a polypeptide capsule of poly-gamma-D-glutamic acid (gammaDPGA). gammaDPGA is poorly immunogenic and has antiphagocytic properties. The bacterial capsule is essential for virulence. Antibodies to the capsule have been shown to enhance phagocytosis and killing of encapsulated...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Rachel Schneerson, Joanna Kubler-kielb, Lily Zhongdong Dai, Zhaochun Chen

Keywords(s): Anthracis, Anthrax, antibodies, Autoimmune polyendocrinopathy syndrome, type 1, Bacillus, Capsule, chimeric, Chimpanzee/Human, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, KILL, monoclonal, Opsonophagocytosis, ORGANISM, Patent Category - Biotechnology, PGA 1, PGA 2, REACT, Schmidt syndrome, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease

Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections

Over the past decade, Staphylococcus epidermidis has become the most prevalent pathogen involved in nosocomial infections. Usually an innocuous commensal microorganism on human skin, this member of the coagulase-negative group of staphylococci can cause severe infection after penetration of the epidermal protective barriers of the human body. In the...

Published: 7/25/2024 | Inventor(s): Yufeng Yao, Jovanka Voyich, Cuong Vuong, Stanislava Kocianova, Frank DeLeo, Michael Otto

Keywords(s): Capsule, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, Edidermis, Poly-gamma-DL-glutamate, Staphylococcus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease