Method of Enhancing Opsonophagocytosis

Description:
This invention aims to bolster the human body's own mechanisms to fight infection by enhancing an innate immune response, opsonophagocytosis. The specific 24 amino acid sequence (P4) acts as a polymorphonuclear cell activator. P4 can be administered in vivo along with a disease's specific antibody to enhance systemic bacterial clearance, thus leading to prolonged survival. This technology enhances the body's response to infections such as S. pneumoniae and S. aureus.
Patent Information:
For Information, Contact:
Jonathan Motley
Fellow
NIH Technology Transfer
jonathan.motley@nih.gov
Inventors:
GowriSankar Rajam
Sandra Steiner
George Carlone
Nikkol Atwell-Melnick Melnick
Jacquelyn Sampson
Joseph Martinez
Joseph Caba
Edwin Ades
Keywords:
ANTIGEN
CDC Docket Import
CDC Docket Import CDC Prosecuting
DA3XXX
DAXXXX
DB3XXX
DB5XXX
DBXXXX
DC1XXX
DC4XXX
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ENHANCING
Epitopes
FUNCTIONAL
Listed LPM Surabian as of 4/15/2015
Methods
OID-NCIRD-DBD
Opsonophagocytosis
PATHOGEN
PNEUMONIAE
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
PsaA
RESPONSE
Streptococcus
THEREOF
USES
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