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Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins
Case ID:
TAB-903
Web Published:
12/6/2022
Description:
The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each year. The virus has been designated into category B of the CDC biodefense-related priority pathogens because it can be used as an agent of bioterrorism. The subject cDNA clone of the virus encodes proteins of the MD145-12 strain that, when expressed in vitro, exhibit properties that would be expected from those produced by the original infectious virus. This cDNA clone is presently the only source to obtain norovirus proteins to facilitate studies aimed at developing control strategies such as vaccines and therapeutic drugs.
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Direct Link:
https://nih.technologypublisher.com/tech/Full-Length_cDNA_Clone_Representing_ the_Consensus_Sequence_of_the_RNA_Genome_of_a_Human_Norovirus_(strain_MD145- 12)_That_Encodes_Biologically_Active_Proteins
Category(s):
Collaboration
Licensing
Materials Available
Vaccines
Infectious Disease
Research Materials
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For Information, Contact:
Inteum Admin
NIH Technology Transfer
Inventors:
Stanislav Sosnovtsev
Lisbeth Kim Green
Gael Belliot
Keywords:
Active
Biological
cDNA
CLONE
CONSENSUS
DC5BXX
DCXXXX
DDXXXX
DXXXXX
ENCODES
FULL-LENGTH
Genome
Human
MD145-12
Norovirus
proteins
Respresenting
RNA
sequence
Strain
That
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