Search Results - nc4xxx

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Generation of mutant mouse alleles that functionally disrupt production of BDNF from its ndividual promoters

This technology relates to a mouse model that improves an existing method of disrupting the production of the BDNF protein in specific parts of the brain. A current avenue of research seeks to examine how gene expression may effect long-lasting changes in the nervous system. Previous work has resulted in a mouse line in which the production of BDNF...

Published: 10/28/2024 | Inventor(s): Keri Martinowich

Keywords(s): ALLELES, AXXXXX, BDNF, DISRUPT, FUNCTIONALLY, Generation, Indiividual, Mouse, MUTANT, NC4XXX, NCXXXX, production, PROMOTERS, That, VEXXXX, WIXXXX, XEXXXX

Category(s): TherapeuticArea > Neurology, Application > Research Materials, Application > Therapeutics

Serotonin-Deficient Knock-out Mouse

Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of serotonin receptor subtypes and it is present in several...

Published: 10/28/2024 | Inventor(s): Dennis Murphy

Keywords(s): AC6XXX, ACXXXX, AXXXXX, KNOCK-OUT, Mouse, MXXXXX, NC4XXX, NCXXXX, NXXXXX, Serotonin-Deficient, VEXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Neurology, Application > Diagnostics, Application > Research Materials