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Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 9/18/2024 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation

Summary: The National Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementing the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...

Published: 9/18/2024 | Inventor(s): Thien Nguyen, Amir Gandjbakhche, Soongho Park, Brian Hill

Keywords(s):

Category(s): Application > Medical Devices, Collaboration Sought > Collaboration, TherapeuticArea > Respiratory, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease

Methods of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies

Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...

Published: 9/13/2024 | Inventor(s): Scott Norberg, Andrew Sinkoe, Xiaolin Wu, James Gulley

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology

Improved Methods For Cryopreservation Of Cells, Tissues, And Organs

Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...

Published: 9/9/2024 | Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge

Keywords(s):

Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

Using Artificial Intelligence To Diagnose Uveitis

Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can identify retinal vasculitis using color fundus images. Description of Technology: Uveitis is caused by inflammation in the eye that can cause pain and reduce vision. The rate of uveitis in the United States is 1 in every...

Published: 8/14/2024 | Inventor(s): Shilpa Kodati, Jongwoo Kim, Nam Nguyen

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

Using Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration

Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...

Published: 8/14/2024 | Inventor(s): Emily Chew, Zhiyong Lu, Tiarnan Keenan, Wai Wong, Qingyu Chen, Elvira Agron

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

TYROSINASE Gene Therapy for Oculocutaneous Albinism type 1A

Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...

Published: 8/14/2024 | Inventor(s): Brian Brooks, Aman George

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Ophthalmology

Interleukin-27 Producing B-Cell Population and Uses Thereof

Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...

Published: 8/14/2024 | Inventor(s): Charles Egwuagu, Jin Choi

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Neurology, TherapeuticArea > Immunology

Using FDA-approved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration

Summary: The National Eye Institute seeks research co-development partners and/or licensees for a therapy using an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...

Published: 9/18/2024 | Inventor(s): Anand Swaroop, Yu Holly Chen, Samantha Papal, Anupam Mondal, Manju Swaroop, Wei Zheng, Gregory Tawa, Wenwei Huang, Zhiji Luo

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat

Methods of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies

Published: 7/26/2024 | Inventor(s): Scott Norberg, Andrew Sinkoe, Xiaolin Wu, James Gulley

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology

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