Search Results - polypeptides

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Polypeptides for Stimulation of Immune Response (Adjuvants)

Abstract: HMGN polypeptides belong to the high mobility group (HMG) family of chromosomal binding peptides. HMGN polypeptides typically function inside the cell nucleus to bind to DNA and nucleosomes and regulate the transcription of various genes. HMGN polypeptides also can be released by peripheral blood mononuclear cells. However, the extracellular...

Published: 5/22/2024 | Inventor(s): De Yang, Joost Oppenheim, Michael Bustin

Keywords(s): Autoimmune, HMGN, immune response, immunoadjuvant, POLYPEPTIDES, Vaccine Adjuvant

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology

Immunogenic Antigen Selective Cancer Immunotherapy

Abstract: Melanoma is a particularly aggressive form of cancer primarily caused by over-exposure to sunlight. Although melanoma can strike at any age, the malignancy disproportionately impacts persons of advanced age, as these individuals often have decades of repeated exposure to harmful levels of ultraviolet radiation. Scientists at NIH among others...

Published: 4/8/2024 | Inventor(s): Bira Arya, Vladimir Larionov

Keywords(s): MELANOMA, POLYPEPTIDES, SPANX-B

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Scytovirin Domain 1 Related Polypeptides

Abstract: Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics,...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Chang-yun Xiong, James McMahon, R. Andrew Byrd

Keywords(s): HIV, O’Keefe, POLYPEPTIDES, Scytovirin

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics

Dengue Vaccines: Tools for Redirecting the Immune Response for Safe, Efficacious Dengue Vaccination

This CDC-developed invention relates to dengue vaccines that have been specifically developed for improved efficacy and directed immune response to avoid antibody-dependent enhancement (ADE) safety issues that, theoretically, may be associated with dengue vaccines and vaccinations. Dengue viral infection typically causes a debilitating but non-lethal...

Published: 7/25/2024 | Inventor(s): Wayne Crill, Holly Hughes, Brent Davis, Gwong-Jen Chang

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Containing, Cross-Reactive, DB4BXX, DB4XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DENGUE, DNA vaccine, DXXXXX, E-GLYCOPROTEIN, Eliminate, Epitopes, Immunodominant, insect, Insects, Mosquito, Mosquitoes, MULTIVALENT, Mutations, OID-NCEZID-DVBD, POLYPEPTIDES, Serotype, Serotypes, That, Vacccination, Vaccine, Vector-borne, Vector-borne diseases, virus, VLXXXX, WJXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Research Materials, Application > Diagnostics

Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Development

This technology comprises specific hepatitis E virus (HEV) antigenic polypeptides. HEV causes epidemic and sporadic cases of hepatitis outbreaks with a mortality rate as high as 20% for pregnant women. In order to address this problem, CDC scientists carried out thorough HEV antigen screenings and subsequently developed recombinant proteins that efficiently...

Published: 4/8/2024 | Inventor(s): Yury Khudyakov, Jihong Meng, Howard Fields

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, HEV, Immunogenic, Neutralizing, OID-NCHHSTP-DVH, POLYPEPTIDES, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, ResearchProducts > Antibodies, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology

Vaccines Comprising Sand Fly Salivary Proteins for Control of Leishmania Infection

This invention relates to the use of several peptides from the salivary glands of various sand fly species for the control of leishmania infection. Many of these peptides were shown to be effective in eliciting potent immune responses in animal models and are excellent candidates for the development of vaccines against the disease. A vaccine comprising...

Published: 7/25/2024 | Inventor(s): Jesus Valenzuela

Keywords(s): Adn, America, ARIASI, Cellular, Chagase, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, DDXXXX, Dogs, DXXXXX, Efficient, ELICIT, Fly, Identification, IFN-gamma, Immunity, Infantum, KILLING, Latin, LEISHMANIA, LEISHMANIASIS, Leishmaniasis (Leishmania sp.), Listed LPM Stansberry as of 4/15/2015, LJL143, LJM17, Longipalpis, Lutzomyiz, Method, P., Patent Category - Biotechnology, PERNICIOSUS, POLYPEPTIDES, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RESULTING, Salivary, SAND, That, Vector, Visceral, WIPO Re:search

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease