Search Results - vladimir+larionov

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Immunogenic Antigen Selective Cancer Immunotherapy

Abstract: Melanoma is a particularly aggressive form of cancer primarily caused by over-exposure to sunlight. Although melanoma can strike at any age, the malignancy disproportionately impacts persons of advanced age, as these individuals often have decades of repeated exposure to harmful levels of ultraviolet radiation. Scientists at NIH among others...

Published: 4/8/2024 | Inventor(s): Bira Arya, Vladimir Larionov

Keywords(s): MELANOMA, POLYPEPTIDES, SPANX-B

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

High-throughput Assay to Identify New Cancer Drugs

Abstract: The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability. Although chromosomal instability is generally thought of as a driver of tumor growth, a threshold level exists where CIN becomes a barrier to tumor...

Published: 4/8/2024 | Inventor(s): Vladimir Larionov, William Earnshaw

Keywords(s): chromosome instability (CIN), drug discovery, green fluorescent protein labeled chromosome, high-throughput assay

Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Rapid Methods for Human Artificial Chromosome (HAC) Formation

Abstract: Gene therapy is a promising strategy to treat a wide range of human diseases, and several gene therapy vectors have been developed to deliver these novel treatments. However, risks and challenges of using these vectors remain, such as: gene integration, potential infection, immune response and maintaining long term, stable gene expression....

Published: 4/8/2024 | Inventor(s): Vladimir Larionov, William Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Vladimir Noskov, Natalay Kouprina, J. Carl Barrett

Keywords(s): Alphoid DNA arrays, Centromere Seeding, Engineered Centromeric Sequences, Gene expression/delivery system, GENE THERAPY, Human artificial chromosomes (HACs), Mammalian Artificial Chromosomes Larionov, RCA, Recombinational Amplification of Repeats RAR, Rolling-circle amplification, TAR-NV, Transformation-Associated Recombination targeting vector

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Transformation-Associated Recombination (TAR) Cloning

Transformation-Associated Recombination (TAR) cloning in yeast is a unique method for selective isolation of large chromosomal fragments or entire genes from complex genomes without the time-consuming step of library construction.1 The technique involves homologous recombination during yeast spheroplast transformation between genomic DNA and a TAR...

Published: 7/25/2024 | Inventor(s): Vladimir Larionov, Natalay Kouprina, Michael Resnick

Keywords(s): ACXXXX, AXXXXX, GDXXXX, GXXXXX, ICXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics