Search Results - drug+discovery

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High-throughput Assay to Identify New Cancer Drugs

Abstract: The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability. Although chromosomal instability is generally thought of as a driver of tumor growth, a threshold level exists where CIN becomes a barrier to tumor...

Published: 4/8/2024 | Inventor(s): Vladimir Larionov, William Earnshaw

Keywords(s): chromosome instability (CIN), drug discovery, green fluorescent protein labeled chromosome, high-throughput assay

Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Cotranslational Protein Expression System for High-throughput Screening

Reporter gene-based assays are used extensively in high-throughput screening (HTS) to identify chemical modulators of cellular pathways for drug discovery and development. However, such screening frequently results in a large number of false “hits” due to interactions of screened compounds with reporter proteins, producing confounding results. Thus,...

Published: 7/25/2024 | Inventor(s): Chih-Chien (Ken) Cheng, Samuel Hasson, James Inglese

Keywords(s): AC4XXX, ACXXXX, AXXXXX, Coincidence, drug discovery, Drug Screening, High-throughput, High-throughput screen, HTS, REPORTER, reporter gene

Category(s): Collaboration Sought > Collaboration