Search Results - drug+screening

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Summary: NCI is seeking parties to non-exclusively license the A2243 human synovial sarcoma cell line. Description of Technology: Synovial sarcoma is a cancer affecting mesenchymal cells in connective tissues. This rare cancer is typically linked to genetic abnormalities or exposure to radiation. Metastatic growth throughout the body can occur primarily...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Stuart Aaronson, Nelson Ellmore (Estate)

Keywords(s): A2243, Aaronson, Chromosomal Translocation, CONNECTIVE TISSUE, Drug Screening, Human Cell Line, Mesenchymal Cells, Rare Cancer, SSX, Synovial sarcoma, SYT, tumor formation

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Autodock Vina Software Process for Efficient Large-Scale Cognate Ligand Screening

The invention pertains to software processes, additions, and docking approaches to Autodock Vina that speeds the rate and efficiency of analyzing ligand interactions with a receptor by cognate ligands and rewards conformations in the scoring algorithm for residue interactions that are based on the biological data. The score is multiplied by a weighting...

Published: 5/7/2025 | Updated: 12/6/2022 | Inventor(s): Umesh Padia, Elizabeth Geras-Raaka, Marvin Gershengorn

Keywords(s): AD3XXX, ADXXXX, Autodock, COGNATE, Cognate Ligand, Drug Screening, drug screening tool, LIGAND-BINDING, Vina, WIXXXX, WMXXXX, XJXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, ResearchProducts > Computational models/software, Application > Consumer Products, Application > Software / Apps, Application > Research Materials

Cotranslational Protein Expression System for High-throughput Screening

Reporter gene-based assays are used extensively in high-throughput screening (HTS) to identify chemical modulators of cellular pathways for drug discovery and development. However, such screening frequently results in a large number of false “hits” due to interactions of screened compounds with reporter proteins, producing confounding results. Thus,...

Published: 10/28/2024 | Updated: 12/6/2022 | Inventor(s): Chih-Chien (Ken) Cheng, Samuel Hasson, James Inglese

Keywords(s): AC4XXX, ACXXXX, AXXXXX, Coincidence, drug discovery, Drug Screening, High-throughput, High-throughput screen, HTS, REPORTER, reporter gene

Category(s): Collaboration Sought > Collaboration