Search Results - drug+screening

3 Results

Sort By:

Abstract: Synovial sarcoma is a cancer affecting mesenchymal cells in connective tissues. This rare cancer is typically linked to genetic abnormalities or exposure to radiation. Metastatic growth throughout the body can occur primarily through blood circulation. More than 90% of synovial sarcomas show a characteristic t(X;18)(p11;q11) translocation...

Published: 7/25/2024 | Inventor(s): Stuart Aaronson, Nelson Ellmore

Keywords(s): A2243, Aaronson, Chromosomal Translocation, CONNECTIVE TISSUE, Drug Screening, Human Cell Line, Mesenchymal Cells, Rare Cancer, SSX, Synovial sarcoma, SYT, tumor formation

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Autodock Vina Software Process for Efficient Large-Scale Cognate Ligand Screening

The invention pertains to software processes, additions, and docking approaches to Autodock Vina that speeds the rate and efficiency of analyzing ligand interactions with a receptor by cognate ligands and rewards conformations in the scoring algorithm for residue interactions that are based on the biological data. The score is multiplied by a weighting...

Published: 4/8/2024 | Inventor(s): Umesh Padia, Elizabeth Geras-Raaka, Marvin Gershengorn

Keywords(s): AD3XXX, ADXXXX, Autodock, COGNATE, Cognate Ligand, Drug Screening, drug screening tool, LIGAND-BINDING, Vina, WIXXXX, WMXXXX, XJXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, ResearchProducts > Computational models/software, Application > Consumer Products, Application > Software / Apps, Application > Research Materials

Cotranslational Protein Expression System for High-throughput Screening

Reporter gene-based assays are used extensively in high-throughput screening (HTS) to identify chemical modulators of cellular pathways for drug discovery and development. However, such screening frequently results in a large number of false “hits” due to interactions of screened compounds with reporter proteins, producing confounding results. Thus,...

Published: 7/25/2024 | Inventor(s): Chih-Chien (Ken) Cheng, Samuel Hasson, James Inglese

Keywords(s): AC4XXX, ACXXXX, AXXXXX, Coincidence, drug discovery, Drug Screening, High-throughput, High-throughput screen, HTS, REPORTER, reporter gene

Category(s): Collaboration Sought > Collaboration