Search Results - natalay+kouprina

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Rapid Methods for Human Artificial Chromosome (HAC) Formation

Abstract: Gene therapy is a promising strategy to treat a wide range of human diseases, and several gene therapy vectors have been developed to deliver these novel treatments. However, risks and challenges of using these vectors remain, such as: gene integration, potential infection, immune response and maintaining long term, stable gene expression....

Published: 4/8/2024 | Inventor(s): Vladimir Larionov, William Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Vladimir Noskov, Natalay Kouprina, J. Carl Barrett

Keywords(s): Alphoid DNA arrays, Centromere Seeding, Engineered Centromeric Sequences, Gene expression/delivery system, GENE THERAPY, Human artificial chromosomes (HACs), Mammalian Artificial Chromosomes Larionov, RCA, Recombinational Amplification of Repeats RAR, Rolling-circle amplification, TAR-NV, Transformation-Associated Recombination targeting vector

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Transformation-Associated Recombination (TAR) Cloning

Transformation-Associated Recombination (TAR) cloning in yeast is a unique method for selective isolation of large chromosomal fragments or entire genes from complex genomes without the time-consuming step of library construction.1 The technique involves homologous recombination during yeast spheroplast transformation between genomic DNA and a TAR...

Published: 7/25/2024 | Inventor(s): Vladimir Larionov, Natalay Kouprina, Michael Resnick

Keywords(s): ACXXXX, AXXXXX, GDXXXX, GXXXXX, ICXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics