Search Results - barry+o%27keefe

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Modified griffithsin tandemers for enhanced activity and reduced viral aggregation

Abstract: Griffithsin (GRFT) is a lectin with potent antiviral properties that is capable of preventing and treating infections caused by a number of enveloped viruses (including HIV, SARS, HCV, HSV, and Japanese encephalitis) and is currently in clinical development as an anti-HIV microbicide. In addition to its broad antiviral activity, GRFT is stable...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Alexander Wlodawer, Tinoush Moulaei

Keywords(s): ANTIVIRAL, mGRFT tandemers

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics

Anti-Viral Polypeptide Griffithsin: Compounds, Compositions, and Methods of Use

Abstract: This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003). Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral infection, an H5N1...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, James McMahon, Toshiyuki Mori

Keywords(s): Anti-Viral, Corona virus, Ebola, Griffithsin, INFLUENZA, O’Keefe, SARS

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing

Enhanced Cancer Chemotherapy Using the Bioactive Peptide Recifin And Its Analogues

Abstract: Topoisomerase enzymes play an important role in cancer progression by controlling changes in DNA structure through catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. Therefore, topoisomerases are important targets for cancer chemotherapy. Many topoisomerase 1 (TOP1) inhibitors...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Lauren Krumpe, Johan Rosengren, Ingrid Schroeder, Alan Bermingham, Christophe Marchand, Kirk Gustafson, Brice Wilson, Yves Pommier

Keywords(s): CANCER, Chemosensitizing Agents, CHEMOTHERAPY, Cyclic Peptide, Irinotecan TOP1, O’Keefe, Recifin, Tdp1, Topoisomerase 1 inhibitors, Topotecan, Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics

Scytovirin Domain 1 Related Polypeptides

Abstract: Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics,...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Chang-yun Xiong, James McMahon, R. Andrew Byrd

Keywords(s): HIV, O’Keefe, POLYPEPTIDES, Scytovirin

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics

Griffithsin-Based Anti-viral Therapeutics with Improved Stability and Solubility

Abstract: Griffithsin is a potent anti-viral protein with activity against HIV, HCV, Sars, HSV 1 & 2 and other viruses. It is active against HIV and HCV at picomolar concentrations. Griffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development...

Published: 7/16/2024 | Inventor(s): Barry O'Keefe, Kenneth Palmer, Tinoush Moulaei, Lisa Rohan, Joshua Fuqua, Lindsay Kramzer

Keywords(s): Anti-Viral, cnidarin, Griffithsin, HCV, HIV, HSV, SARS

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease

Novel Anti-HIV Proteins from Coral Reefs

Abstract: Scientists at the National Cancer Institute's Molecular Targets Laboratory have discovered that Cnidarins as a novel class of highly potent proteins capable of blocking the HIV virus from penetrating T-cells. Cnidarins were found in a soft coral collected in waters off Australia's northern coast. Cnidarins can block virus fusion/entry but...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, James McMahon, Koreen Ramessar, Chang-yun Xiong

Keywords(s): Anti-Viral, cnidarin, HIV

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

A Triple Combination HIV Microbicide

Abstract: The HIV-positive population continues to rise despite a worldwide decline in the rates of infection caused by human immunodeficiency virus (HIV). The HIV virus continues to spread due to a lack of effective vaccines and pre-exposure prophylaxis methods, even though the availability and effectiveness of antiretroviral therapy has helped reduce...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Paul Christou, Evangelia Vavamka, Theresa Capell

Keywords(s): Acquired Immunodeficiency Syndrome, ANTIBODY, ANTIVIRAL, HIV, Lectin, Microbicide, O’Keefe, Sexually Transmitted Diseases

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

An Anti-Viral Polypeptide: Griffithsin

Abstract: Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host’s immune system and as a preventive and therapeutic antiviral strategy. Plant-derived carbohydrate-binding proteins...

Published: 4/8/2024 | Inventor(s): Michael Boyd, Toshiyuki Mori, Barry O'Keefe

Keywords(s): Griffithsin, O'Keefe, SARS, Severe acute respiratory syndrome

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing