Search Results - tinoush+moulaei

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Modified griffithsin tandemers for enhanced activity and reduced viral aggregation

Abstract: Griffithsin (GRFT) is a lectin with potent antiviral properties that is capable of preventing and treating infections caused by a number of enveloped viruses (including HIV, SARS, HCV, HSV, and Japanese encephalitis) and is currently in clinical development as an anti-HIV microbicide. In addition to its broad antiviral activity, GRFT is stable...

Published: 4/8/2024 | Inventor(s): Barry O'Keefe, Alexander Wlodawer, Tinoush Moulaei

Keywords(s): ANTIVIRAL, mGRFT tandemers

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics

Griffithsin-Based Anti-viral Therapeutics with Improved Stability and Solubility

Abstract: Griffithsin is a potent anti-viral protein with activity against HIV, HCV, Sars, HSV 1 & 2 and other viruses. It is active against HIV and HCV at picomolar concentrations. Griffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development...

Published: 7/16/2024 | Inventor(s): Barry O'Keefe, Kenneth Palmer, Tinoush Moulaei, Lisa Rohan, Joshua Fuqua, Lindsay Kramzer

Keywords(s): Anti-Viral, cnidarin, Griffithsin, HCV, HIV, HSV, SARS

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease