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Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells

This invention relates to novel mouse and rat models that permit the temporal death of neuronal precursor cells at any time point. Other existing methods of decreasing neurogenesis are relatively non-specific (e.g., injecting glucocorticoids) or require expensive equipment (e.g., focal x-irradiation) These mice and rats are being used to inhibit adult...

Published: 7/25/2024 | Inventor(s): James Pickel, Heather Cameron

Keywords(s): Driving, Expression, GFAP, HSV, Kinase, Listed LPM Maddox as of 4/15/2015, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PROMOTER, RATS, Thymidine, TRANSGENIC, VEXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials

Therapeutic and Diagnostic Targets for Severe RSV Infection

Respiratory Syncytial Virus (RSV) infects nearly all children by their second birthday. RSV usually causes mild respiratory illness, however, a subset of patients experience severe infection that require hospitalization. Successful host defense against viral pathogens requires rapid recognition of the virus and activation of both innate and adaptive...

Published: 7/25/2024 | Inventor(s): Daniel Menendez Rendon, Steven Kleeberger, Michael Resnick

Keywords(s): DAXXXX, DBXXXX, DCXXXX, Human, Identifies, Infection, p53, PROMOTER, RESPONSIVE, Risk, RSV, Serious, SNP, TLR8

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility

HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Hspa2-cre expression mimics the spermatogenic cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene is also detected at restricted sites in the brain, as occurs...

Published: 7/25/2024 | Inventor(s): Edward Eddy

Keywords(s): Cells, Cre, EXPRESSED, Gene, Generation, Hspa2, IDXXXX, IXXXXX, Line, Mouse, PROMOTER, Recombinase, REGULATION, Spermatogenesis, Spermatogenic, TRANSGENIC

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics