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A Cell Line that Expresses secNluc and GFP to Recapitulate PMP22 Gene Expression for Studying Peripheral Neuropathy

This technology includes a cell line that expresses two reporters (a secreted luciferase, secNLuc, and GFP) in a pattern that recapitulates the endogenous expression of the peripheral myelin protein 22 (Pmp22) gene. Pmp22 is mainly expressed in the Schwann cells of the peripheral nervous system. Many neurological disorders are associated with aberrations...

Published: 7/25/2024 | Inventor(s): John Svaren, Sung-Wook Jang, James Inglese

Keywords(s): Cell, Coincidence, ENDOGENOUS, ENGINEERED, Express, Expression, Gene, GENETICALLY, GFP, Line, Listed LPM Tong as of 4/15/2015, LOCUS, Pmp22, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Recapitulate, Reporters, SecNluc, That, VEXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials

Rabies Vaccine for the Oral Immunization of Domesticated Animals, Wildlife and Feral Animals

This invention, developed by the CDC and collaborators, entails a live, attenuated recombinant rabies virus vaccine that can elicit an effective anti-rabies immune response in animal recipients. Inoculation with a live, attenuated, rabies virus allows for the optimized production of immunity in the absence of pathogenicity. Oral administration of...

Published: 7/25/2024 | Inventor(s): Charles Rupprecht

Keywords(s): CDC Docket Import, CDC Docket Import NP, DC5BXX, DC5XXX, DCXXXX, Dogs, DXXXXX, ENGINEERED, GENETICALLY, Immunization, rabies, recombinant, Stray, Vaccine, VLXXXX, VOXXXX, WFXXXX, Wildlife, WJXXXX, WMXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, Application > Consumer Products

Modified AAV5 Vectors for Enhanced Transduction and Reduced Antibody Neutralization

Scientists at the NIH disclosed a mutated adeno-associated virus (AAV) serotype 5 by modifying sialic acid binding regions which mediate viral entry into host cells. Preliminary results from animal studies suggest that this modification can increase transduction by 3-4 folds in salivary glands and muscles, and can significantly decrease the potential...

Published: 7/25/2024 | Inventor(s): Sandra Afione-Wainer, Mavis Agbandje-Mckenna, Sujata Halder, John (Jay) Chiorini

Keywords(s): AAV5, ANTIBODY, ENGINEERED, Enhanced, GENETICALLY, Listed LPM Reichman as of 4/15/2015, Neutralization, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REDUCED, transduction, VAXXXX, VCXXXX, vectors, VFXXXX, VGXXXX, WJXXXX, XEXXXX, YAXXXX, YCXXXX

Category(s): TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Therapeutics