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A Cell Line that Expresses secNluc and GFP to Recapitulate PMP22 Gene Expression for Studying Peripheral Neuropathy

This technology includes a cell line that expresses two reporters (a secreted luciferase, secNLuc, and GFP) in a pattern that recapitulates the endogenous expression of the peripheral myelin protein 22 (Pmp22) gene. Pmp22 is mainly expressed in the Schwann cells of the peripheral nervous system. Many neurological disorders are associated with aberrations...

Published: 7/25/2024 | Inventor(s): John Svaren, Sung-Wook Jang, James Inglese

Keywords(s): Cell, Coincidence, ENDOGENOUS, ENGINEERED, Express, Expression, Gene, GENETICALLY, GFP, Line, Listed LPM Tong as of 4/15/2015, LOCUS, Pmp22, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Recapitulate, Reporters, SecNluc, That, VEXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials

Myosin-Based Protein-Protein Interaction Assay

Investigators at the National Institute on Deafness and Other Communication Disorders (NIDCD) have developed an assay for the detection of protein-protein interactions in living cells. This assay uses readily-available reagents and straightforward techniques that avoid the difficulty of purifying proteins or generating antibodies required for other...

Published: 7/25/2024 | Inventor(s): Thomas Friedman, Inna Belyantseva, Erich Boger

Keywords(s): [DC-023], [DC-024], [DC-025], [DC-026], [DC-027], [DC-028], [DC-029], 10, AC4XXX, AC5XXX, ACXXXX, assay, AXXXXX, cDNA, cDNAS, chimeric, Cloning, DsRed-tagged, ELEVEN, Flourescent, fluorescent, Fluorescent probe, Fourteen, Fusion, GFP, GFP-Myo, GFP-Myo10, GFP-MyolO, GFP-myosin, GFp-whirlin, GREEN, HEAVY, HMM, INTERACTION, KINESIN, Meromyosin, Mouse, MYOSIN, ONE, Patent Category - Biotechnology, Plasmic, PLASMID, Protein, PROTEIN-PROTEIN, PROTEIN-PROTEIN interactions, SIX, Sixteen, TAGGED, Twenty, Twenty-two, whirlin, X, XVa

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available