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Role of Novel Hepatitis Delta Virus Variant in Sjogren’s Syndrome

Sjögren’s is a chronic autoimmune disease characterized by dry mouth and eyes, fatigue, and musculoskeletal pain resulting from the attack of the moisture-producing glands by the body’s own white blood cells. The subject invention is based on the discovery of an association between infection by a novel clade 1 variant of hepatitis delta virus (HDV)...

Published: 10/28/2024 | Inventor(s): Melodie Weller, John (Jay) Chiorini

Keywords(s): DAXXXX, DBXXXX, DELTA, detected, GLANDS, Hepatitis, Salivary, Sjgrens, Syndrome, VAXXXX, virus, VLXXXX, WBXXXX, WIXXXX, WJXXXX, WKXXXX, XAXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Geriatrics, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies

Diagnostic Test and Therapeutic Target for Sjogren's Syndrome

Sjögren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes. Currently, there is no single diagnostic test to confirm the presence of Sjögren's. Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further...

Published: 10/28/2024 | Inventor(s): Melodie Weller, Hongen Yin, John (Jay) Chiorini

Keywords(s): Alteration, BMP6, Detection, Diagnosis, Expression, Gland, IA3XXX, IAXXXX, IXXXXX, LEVELS, Listed LPM Contreras as of 4/15/2015, Locally, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Salivary, Sjogren's, Syndrome, treatment

Category(s): TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Identification of EGFR as A Receptor for AAV6 Transduction

AAV vectors offer unique advantages in gene therapy applications. Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems. Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a...

Published: 10/28/2024 | Inventor(s): Michael Schmidt, Melodie Weller, John (Jay) Chiorini

Keywords(s): AAV6, EGFR, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GXXXXX, Identification, RECEPTOR, transduction

Category(s): Application > Therapeutics