Search Results - egfr

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A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma

Abstract: Previously described epidermal growth factor receptor- (EGFR) driven tumor mouse models develop diffuse tumors, which are dissimilar to human lung tumor morphology and difficult to measure by CT and MRI scans. Scientists at the National Cancer Institute (NCI) have developed and characterized a genetically engineered mouse (GEM) model of human...

Published: 4/8/2024 | Inventor(s): Simone Difilippantonio, Lionel Feigenbaum, Deborah Householder, Philip Martin, Zoe Ohler, Terry Van Dyke

Keywords(s): EGFR, Epidermal Growth Factor Receptor, GEM, Genetically Engineered Mouse, Lung adenocarcinoma, lung cancer, mouse model, Ohler Weaver, respiratory

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology

EGFRvIII Antibodies for the Treatment of Human Cancer

Abstract: Epidermal growth factor receptor variant III (EGFRvIII) is a variant of EGFR that is an excellent target for immunotherapy because of its expression in cancer cells and not in normal cells. Inventors from the National Cancer Institute (NCI) have isolated seven mouse monoclonal antibodies that bind to the human EGFRvIII but not wildtype EGFR....

Published: 4/8/2024 | Inventor(s): David Fitzgerald, Antonella Antignani, Eric Ho, Robert Sarnovsky

Keywords(s): ADC, Antibody-drug Conjugate, CAR, chimeric antigen receptor, EGFR, EGFRvIII, Epidermal Growth Factor Receptor, Epidermal growth factor receptor variant III, FitzGerald, Recombinant Immunotoxins, RITs

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Identification of EGFR as A Receptor for AAV6 Transduction

AAV vectors offer unique advantages in gene therapy applications. Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems. Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a...

Published: 7/25/2024 | Inventor(s): Michael Schmidt, Melodie Weller, John (Jay) Chiorini

Keywords(s): AAV6, EGFR, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GXXXXX, Identification, RECEPTOR, transduction

Category(s): Application > Therapeutics