Search Results - terry+van+dyke

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A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer

Abstract: Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Scientists at the National Cancer Institute (NCI) have developed and characterized an orthotopic...

Published: 4/8/2024 | Inventor(s): Zoe Ohler, Rajaa El Meskini, Anthony Lacovelli, Alan Kulaga, Michelle Gumprecht, Terry Van Dyke

Keywords(s): Brain Cancer, GBM, GEM, Genetically Engineered Mouse, Meskini, mouse model, Multiforme, Ohler Weaver, Orthotopic Glioblastoma

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology

Metastatic ovarian cancer mouse models and cell lines for preclinical studies

Abstract: The high mortality rate from ovarian cancers can be attributed to late-stage diagnosis and lack of effective treatment. Despite enormous effort to develop better targeted therapies, platinum-based chemotherapy still remains the standard of care for ovarian cancer patients, and resistance occurs at a high rate. One of the rate limiting factors...

Published: 4/8/2024 | Inventor(s): Simone Difilippantonio, Terry Van Dyke, Ludmila Szabova, Chaoying Yin, Yurong Song

Keywords(s): GDA, GEM Derived Allograft Mouse Model, Genetically Engineered Mouse (GEM) Model, OVARIAN CANCER, SEOC, Serous Epithelial Ovarian Cancer

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Mouse Model for the Preclinical Study of Metastatic Disease

Abstract: The successful development of new cancer therapeutics requires reliable preclinical data that are obtained from mouse models for cancer. Human tumor xenografts, which require transplantation of human tumor cells into an immune compromised mouse, represent the current standard mouse model for cancer. Since the immune system plays an important...

Published: 5/23/2024 | Inventor(s): Chi-Ping Day, Glenn Merlino, Terry Van Dyke, Zoe Ohler

Keywords(s): Carcinoma, neoplasm, non small cell lung, treatment outcome, xenograft mouse

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Murine metastatic pancreatic adenocarcinoma cell lines

Abstract: Researchers at the National Cancer Institute (NCI) have developed orthotopic allograft models for pancreatic cancer that utilize low passage primary pancreatic adenocarcinoma cells or tumor fragments implanted into the cancer-free pancreata of recipient syngeneic immunocompetent mice. Tumor development in these models is more synchronized,...

Published: 4/8/2024 | Inventor(s): Serguei Kozlov, Ludmila Szabova, Melanie Gordon, Myhaymin Kamal, Jerome Schlomer, Theresa Guerin, Theresa O'Sullivan, Terry Van Dyke

Keywords(s): ADENOCARCINOMA, CANCER, GEM-Derived Allograft, Inflammation, Kozlov, Mouse Models, Pancreatic

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma

Abstract: Previously described epidermal growth factor receptor- (EGFR) driven tumor mouse models develop diffuse tumors, which are dissimilar to human lung tumor morphology and difficult to measure by CT and MRI scans. Scientists at the National Cancer Institute (NCI) have developed and characterized a genetically engineered mouse (GEM) model of human...

Published: 4/8/2024 | Inventor(s): Simone Difilippantonio, Lionel Feigenbaum, Deborah Householder, Philip Martin, Zoe Ohler, Terry Van Dyke

Keywords(s): EGFR, Epidermal Growth Factor Receptor, GEM, Genetically Engineered Mouse, Lung adenocarcinoma, lung cancer, mouse model, Ohler Weaver, respiratory

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Genetically Engineered Mouse-Derived Allograft for Preclinical Studies of Metastatic Melanoma

Abstract: The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Before testing drugs in humans, drug developers are required...

Published: 5/23/2024 | Inventor(s): Chi-Ping Day, Glenn Merlino, Zoe Ohler, Rajaa El Meskini, Terry Van Dyke, Thomas Tuting

Keywords(s): Allograft, GDA, Genetically Engineered Mouse-Derived Allograft, MELANOMA, Metastasis, mouse model, Preclinical, therapeutics

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology