Search Results - carcinoma

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Mouse Model for the Preclinical Study of Metastatic Disease

Abstract: The successful development of new cancer therapeutics requires reliable preclinical data that are obtained from mouse models for cancer. Human tumor xenografts, which require transplantation of human tumor cells into an immune compromised mouse, represent the current standard mouse model for cancer. Since the immune system plays an important...

Published: 5/23/2024 | Inventor(s): Chi-Ping Day, Glenn Merlino, Terry Van Dyke, Zoe Ohler

Keywords(s): Carcinoma, neoplasm, non small cell lung, treatment outcome, xenograft mouse

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Prevention of Head and Neck Cancer Using Rapamycin and Its Analogs

It is frequently observed in head and neck squamous cell carcinoma (HNSCC), a cancer occurring mostly in the mouth, that the Akt/mTOR pathway is abnormally activated. Therefore, inhibiting this signaling pathway may help in treating this disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they could serve as...

Published: 7/25/2024 | Inventor(s): Panomwat Amornphimoltham, Rakefet Czerninski, Vyomesh Patel, Alfredo Molinolo, J Silvio Gutkind

Keywords(s): (4)r syndrome, C syndrome, Carcinoma, CBXXXX, CHEMOPREVENTIVE, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Cowden's disease, Cowden's syndrome, CXXXXX, G syndrome, HEAD, Hypertelorism with esophageal abnormality and hypospadias, Listed LPM Campbell as of 4/15/2015, MTOR-inhibitors, N syndrome, NECK, Patent Category - Biotechnology, Patent Category - Chemistry, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Rapamycin, SQUAMOUS, Squamous cell carcinoma, Syndrome X, W syndrome, W syndrome; Syndrome W

Category(s): Application > Therapeutics, TherapeuticArea > Oncology

Agonist Epitopes for Renal Cell Carcinoma

Approximately 30,000 patients are diagnosed with renal cell carcinoma (RCC) each year in the United States, and an estimated 12,000 patients die of this disease. Most patients are diagnosed with advanced local disease or metastatic disease. Metastatic RCC carries a poor prognosis with median survivals in the range of 10-12 months. Drugs that inhibit...

Published: 7/25/2024 | Inventor(s): Richard Childs

Keywords(s): BBXXXX, CA1AXX, CA1XXX, CA2CXX, CA2XXX, Carcinoma, CAXXXX, CB2BXX, CB2XXX, CB4XXX, CBXXXX, Cell, Cells, CXXXXX, Discovery, Expression, Gene, Kidney cancer, adult, Patent Category - Biotechnology, previously, RDD, RENAL, Renal cell carcinoma 1, Renal cell carcinoma 4, Restricted, Uncharacterized, WHOSE

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Oncology