Search Results - brain+cancer

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A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer

Abstract: Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Scientists at the National Cancer Institute (NCI) have developed and characterized an orthotopic...

Published: 4/8/2024 | Inventor(s): Zoe Ohler, Rajaa El Meskini, Anthony Lacovelli, Alan Kulaga, Michelle Gumprecht, Terry Van Dyke

Keywords(s): Brain Cancer, GBM, GEM, Genetically Engineered Mouse, Meskini, mouse model, Multiforme, Ohler Weaver, Orthotopic Glioblastoma

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology

Size-dependent brain distribution of macromolecular drug delivery platform

Abstract: The blood brain barrier (BBB) is a specialized endothelium that prevents the uptake of substances from the systemic circulation into the central nervous system. This barrier, while protecting the sensitive physiological environment of the brain, is also a major impediment in administering therapeutics that need to pass through the BBB. A drug...

Published: 4/8/2024 | Inventor(s): Stephan Stern, David Stevens

Keywords(s): BBB, Blood-brain Barrier, Brain Cancer, Controlled Drug Release, Drug Delivery Platform, Neurological Disorders, Stern

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology