Search Results - brain+cancer

2 Results

Sort By:

A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer

Description of Technology: Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Scientists at the National Cancer Institute (NCI) have developed and characterized...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Zoe Ohler, Rajaa El Meskini, Anthony Lacovelli, Alan Kulaga, Michelle Gumprecht, Terry Van Dyke

Keywords(s): Brain Cancer, GBM, GEM, Genetically Engineered Mouse, Meskini, mouse model, Multiforme, Ohler Weaver, Orthotopic Glioblastoma

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology

Size-dependent brain distribution of macromolecular drug delivery platform

Summary: The NCI seeks research co-development partners and/or licensees for a selective polylysine succinylated (PLS) drug delivery platform. Description of Technology: The blood brain barrier (BBB) is a specialized endothelium that prevents the uptake of substances from the systemic circulation into the central nervous system. This barrier, while...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Stephan Stern, David Stevens

Keywords(s): BBB, Blood-brain Barrier, Brain Cancer, Controlled Drug Release, Drug Delivery Platform, Neurological Disorders, Stern

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology