Search Results - darryl+zeldin

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Cytochrome P450 CYP2J Polyclonal Antibodies and Recombinant Proteins for Immunoblotting and Metabolism Studies

This technology includes identified members of the mouse cytochromes P450 CYP2J subfamily and antibodies to them for P450 expression studies and metabolism research. Recombinant proteins of the CYP2J subfamily members have also been expressed. The CYP2J subfamily members have a wide tissue distribution and may be useful as model systems for studies...

Published: 8/12/2024 | Inventor(s): Joan Graves, Darryl Zeldin, Joyce Goldstein, Jennifer Bradbury, Joyce Blaisdell

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Antibodies, ResearchProducts > Plasmids/Vectors, TherapeuticArea > Metabolic Disease

Inhibition of Epoxide Hydrolase 1 in the Treatment of Cardiovascular Diseases

This technology includes EPHX1/EPHX2 null mice and showed that disruption of both EPHX1 and EPHX2 almost completely abolished hydrolysis of several EETs which can be used in the treatment of cardiovascular diseases. EPHX 1 is significantly involved in EET hydrolysis, and we believe the combined use of EPHX1 and EPHX2 inhibitors would provide a better...

Published: 8/12/2024 | Inventor(s): Matthew Edin, Darryl Zeldin

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, ResearchProducts > Animal Models, TherapeuticArea > Cardiology

Cytochromes P450 CYP2J and CYP2C Polyclonal Antibodies and Recombinant Proteins

The National Institutes of Health announces polyclonal antibodies against mouse cytochrome P450s CYP2J and CYP2C. Cytochrome P450s catalyze the metabolism of a wide range of exogenous compounds, including drugs, industrial chemicals, environmental pollutants, and carcinogens. The 2C family of cytochrome P450 metabolizes an extensive number of drugs...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin

Keywords(s): antibodies, CYP2C, CYP2J, CYTOCHROMES, IDXXXX, IXXXXX, P450, polyclonal, proteins, recombinant

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Mouse Model for Study of Diabetic Nephropathy and Role of Soluble Epoxide Hydrolase

Diabetic nephropathy (DN) is the leading cause of renal failure and is characterized by proteinuria that progresses to renal inflammation and decline in the glornerular filtration barrier (GFB). Podocytes are specialized epithelia cells in the glomerular capsule that have a role in filtration of blood and maintaining the integrity of the GFB; dysfunction...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin

Keywords(s): COMPOSITION, Methods, Nephropathy, TREATING, VFXXXX, VPXXXX, WIXXXX, WJXXXX, WKXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology

Isolation of Hybridomas Producing Monoclonal Antibodies (MAbs) Inhibitory to Human CYP2J2

The National Institutes of Health announces three specific monoclonal antibodies that strongly inhibit and/or immunoblot the human cytochrome P450 2J2 (CYP2J2). Cytochrome P450s catalyze the NADPH-dependent oxidation of arachidonic acid to various eicosanoids found in several species. The eicosanoids are biosynthesized in numerous tissues including...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin

Keywords(s): IDXXXX, IXXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Diagnostics and Therapeutics for Hydrocephalus

Congenital hydrocephalus is a significant public health problem, affecting approximately one in 500 live births in the United States. Congenital hydrocephalus has an adverse effect on developing brain and may persist as neurological defects in children and adults. Some of these defects may manifest as mental retardation, cerebral palsy, epilepsy and...

Published: 7/25/2024 | Inventor(s): Perry Blackshear, Darryl Zeldin, Joan Graves, Deborah Stumpo

Keywords(s): BBXXXX, Hydrocephalus, IAXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Development of Reagents to Examine the Expression and Function of CYP2J Subfamily P450s

Cytochrome P450s catalyze the metabolism of a wide range of exogenous compounds, including drugs, industrial chemicals, environmental pollutants, and carcinogens. The 2C family of cytochrome P450 metabolizes an extensive number of drugs which include tolbutamide, S-Warfarin, mephenytoin, diazepam and taxol. The inventors cloned the cDNAs for several...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin, Jennifer Bradbury

Keywords(s): CYP2J, Development, Examine, Expression, FUNCTION, Listed LPM Contreras as of 4/15/2015, P450s, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R1XXXX, REAGENTS, RXXXXX, SUBFAMILY

Category(s): Collaboration Sought > Collaboration, Application > Research Materials