Search Results - mammalian

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A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells

Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...

Published: 7/25/2024 | Inventor(s): Qi Zhang, Yihong Ye

Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials

Novel Targets to Prevent Borrelia burgdorferi Infection and Lyme Disease

B. burgdorferi-infected ticks can cause Lyme disease in mammalian hosts. This technology relates to the use of B. burgdorferi outer surface proteins (BBA64 and BBA66) as Lyme disease vaccine candidates. In vivo animal studies demonstrate these outer surface proteins inhibit tick-to-host B. burgdorferi transmission. Presently, there is no vaccine approved...

Published: 4/8/2024 | Inventor(s): Robert Gilmore

Keywords(s): BBA66, BORRELIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, COMPONENT, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DXXXXX, Gene, Infectivity, MAMMALIAN, Necessary, PATHOGEN, TICK, TRANSMISSION, Vector, Via

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Diagnostics

Zuma Mutant Mice as a Tool for Investigating Mammalian Developmental Defects

In vertebrates, mutations in different ribosomal protein subunits result in a variety of phenotypes, suggesting unique and perhaps extra-ribosomal functions for these proteins. Diamond-Blackfan Anemia (DBA) is a ribosomal protein disease, in which the bone marrow fails to produce red blood cells. NHGRI investigators recently generated a mouse line with...

Published: 7/25/2024 | Inventor(s): Dawn Watkins-Chow, William ("Bill") Pavan

Keywords(s): 57, anemia, CAUSING, DEFECTS, Development, Diamond-Biackfan, INVESTIGATING, MAMMALIAN, Mouse, MUTANT, Protein, Ribosomal, RPS7, RXXXXX, Small, Such, THOSE, Tool

Category(s): Collaboration Sought > Collaboration, Application > Research Materials

ARH3, a Therapeutic Target for Cancer, Ischemia, and Inflammation

ADP-ribosylation is important in many cellular processes, including DNA replication and repair, maintenance of genomic stability, telomere dynamics, cell differentiation and proliferation, and necrosis and apoptosis. Poly-ADP-ribose is important in a number of critical physiological processes such as DNA repair, cellular differentiation, and carcinogenesis....

Published: 7/25/2024 | Inventor(s): Joel Moss

Keywords(s): Activity, Alpha-NAD, Alpha-NADase, ARH3, CB6XXX, CBXXXX, Cell, CXXXXX, Enzyme, Hydrolase:, IB6XXX, IBXXXX, Ihe, IXXXXX, LEVELS, Maintenance, MAMMALIAN, MAY, PAR, PARG-like, Patent Category - Biotechnology, Poly-ADP-ribose, RELEVANT

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Reproductive Health, Application > Diagnostics, Application > Research Materials